Pyridine-2,4-Diamine: Comprehensive User Guide
Table of Contents
1. Product Overview & Key Parameters
Pyridine-2,4-Diamine Specifications
| Parameter | Value | Competitor A (Pyridine-2,6-Diamine) | Competitor B (Benzene-1,3-diamine) |
|---|---|---|---|
| CAS Number | 452-58-4 | 16893-09-9 | 108-45-2 |
| Purity | ≥99.5% | ≥98% | ≥97% |
| Solubility | Water, Ethanol, DMSO | Limited in water | Moderate in polar solvents |
Key Advantages: Superior thermal stability (up to 250°C), enhanced reactivity in cross-coupling reactions, and low heavy metal content (<5ppm).
2. Applications & Use Cases
Core Industrial Applications
- Pharmaceutical Intermediates: Synthesis of antiviral agents (e.g., HIV protease inhibitors)
- Organic Catalysis: Ligand in palladium-catalyzed Suzuki-Miyaura reactions
- Agrochemicals: Key component in fungicide formulations
3. Operational Guidelines
Handling Protocol
| Step | Condition | Optimal Range |
|---|---|---|
| Storage | Inert atmosphere | N2 or Argon, 15-25°C |
| Reaction Setup | Molar ratio | 1:1.2 (Substrate:Pyridine-2,4-Diamine) |
4. Industry Case Studies
Case 1: Anticancer Drug Synthesis
Challenge: Achieve >90% yield in imatinib intermediate synthesis.
Solution: Used 0.5mol% Pyridine-2,4-Diamine as co-catalyst.
Result: 93.2% yield with 99.1% HPLC purity.
5. Client Success Stories
PharmaHealth Ltd. (Shanghai)
Project: Scale-up of hepatitis C NS5A inhibitor
Metrics: Reduced production costs by 18% through improved reaction efficiency.
6. Contact for Custom Solutions
Request tailored technical packages:
Email: info@vivalr.com
Tel: (86) 15866781826
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