Parameter | Pyridinium Tribromide | Elemental Bromine | N-Bromosuccinimide |
---|---|---|---|
CAS Number | 39416-48-3 | 7726-95-6 | 128-08-5 |
Bromine Content | 71.2% | 100% | 44.7% |
Handling Safety | Non-volatile solid | Toxic vapor | Moisture-sensitive |
Reaction Selectivity | High (>90%) | Moderate (60-75%) | Variable (50-85%) |
Enables controlled mono-bromination of activated aromatics at 0-25°C with 92-97% regioselectivity.
Facilitates stereospecific addition to alkenes (trans-addition) in aprotic solvents with 85-93% yield.
Reaction: Bromination of 5-membered heterocycle
Conditions: 1.2eq reagent in DCM at -10°C
Outcome: 89% isolated yield, >99% HPLC purity
Client: Top 5 pesticide manufacturer
Application: Synthesis of brominated fumigants
Result: 22% process efficiency improvement
Challenge: Low-yield bromination in API synthesis
Solution: Transition to pyridinium tribromide system
Metrics: 78% → 94% yield, 35% cost reduction
Email: info@vivalr.com
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