4-Chloro-6-methoxypyrimidine

Table of Contents

• 1. Product Overview
• 2. Specifications & Comparative Analysis
• 3. Key Applications
• 4. Usage Guidelines
• 5. Industry Case Studies
• 6. Request Customized Solutions

1. Product Overview

4-Chloro-6-methoxypyrimidine (CAS 1005-02-3) is a heterocyclic aromatic organic compound widely used in pharmaceutical intermediates and agrochemical synthesis. Molecular formula: C₅H₅ClN₂O. Molecular weight: 144.56 g/mol. Appearance: White to off-white crystalline powder.

2. Specifications & Comparative Analysis

3. Key Applications

3.1 Pharmaceutical Intermediates

Critical component in synthesis of kinase inhibitors (e.g., EGFR inhibitors) and antiviral agents.

3.2 Agrochemical Production

Used in development of pyrimidine-based fungicides and herbicides with enhanced environmental stability.

3.3 Material Science

Building block for liquid crystal materials and organic conductive polymers.

4. Usage Guidelines

4.1 Storage Recommendations

– Store in airtight containers at 2-8°C
– Protect from light and moisture

4.2 Safety Protocols

– Use PPE including chemical goggles and nitrile gloves
– Implement local exhaust ventilation

4.3 Reaction Optimization

Typical reaction conditions for nucleophilic substitution: 80-100°C in DMF with K₂CO₃ as base.

5. Industry Case Studies

Case 1: Anticancer Drug Development

Client: Top 10 Global Pharma Company
Application: Synthesis of third-generation EGFR-TKI inhibitor
Result: Achieved 92% yield in key coupling reaction through optimized purification process

Case 2: Next-Gen Fungicide Formulation

Client: European Agrochemical Producer
Application: Development of systemic fungicide against wheat rust
Result: Improved field efficacy by 40% compared to traditional triazole compounds

6. Request Customized Solutions

Contact our technical team for:
– Custom synthesis services
– Bulk pricing (100kg+ quantities)
– Regulatory support (REACH, FDA DMF)
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