1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine (CAS 923-61-5): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine (CAS 923-61-5), commonly known as DPPE, is a synthetic phospholipid widely used in pharmaceutical and biotechnological research.
Key Parameters:
| Parameter | DPPE | DMPC | DPPC |
|---|---|---|---|
| Molecular Weight | 744.03 g/mol | 678.94 g/mol | 734.04 g/mol |
| Phase Transition Temp | 63°C | 24°C | 41°C |
| Applications | Drug delivery, membrane studies | Model membranes | Liposomal formulations |
2. Key Applications & Use Cases
2.1 Pharmaceutical Development
DPPE serves as a critical component in:
- Lipid nanoparticle (LNP) formulations for mRNA vaccines
- Targeted drug delivery systems
2.2 Biomedical Research
Used in membrane:
- Artificial cell membrane construction
- Membrane protein stabilization studies
3. Industry Applications with Detailed Examples
Case 1: Liposome Preparation
Protocol:
- Dissolve DPPE in chloroform (10 mg/mL)
- Create thin film via rotary evaporation
- Hydrate with PBS buffer (pH 7.4)
Case 2: Cell Membrane Mimetics
DPPE enables creation of stable:
- Supported lipid bilayers for biosensors
- Membrane raft studies
4. Customer Success Stories
4.1 Merck KGaA
Challenge: Required stable liposomes for antibody conjugation
Solution: DPPE-based formulations showed 92% encapsulation efficiency
Result: 40% improvement in shelf-life stability
4.2 Avanti Polar Lipids
Utilized DPPE in:
– Custom membrane protein studies
– Achieved 2.8Å resolution in cryo-EM analysis
5. Request a Quote
Contact our technical team for:
- Bulk pricing (10g-100kg quantities)
- GMP-grade specifications
- Custom lipid formulation services
Email: info@vivalr.com
Tel: (86) 15866781826



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