1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine CAS 923-61-5

Chemical Name: 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine
CAS No.: 923-61-5
Molecular Fomula: C37H74NO8P
Molecular weight: 691.97
Appearance: White to light white powder

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1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine (CAS 923-61-5): Comprehensive User Guide

1. Product Overview & Specifications

1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine (CAS 923-61-5), commonly known as DPPE, is a synthetic phospholipid widely used in pharmaceutical and biotechnological research.

Key Parameters:

Parameter DPPE DMPC DPPC
Molecular Weight 744.03 g/mol 678.94 g/mol 734.04 g/mol
Phase Transition Temp 63°C 24°C 41°C
Applications Drug delivery, membrane studies Model membranes Liposomal formulations

2. Key Applications & Use Cases

2.1 Pharmaceutical Development

DPPE serves as a critical component in:

  • Lipid nanoparticle (LNP) formulations for mRNA vaccines
  • Targeted drug delivery systems

2.2 Biomedical Research

Used in membrane:

  • Artificial cell membrane construction
  • Membrane protein stabilization studies

3. Industry Applications with Detailed Examples

Case 1: Liposome Preparation

Protocol:

  1. Dissolve DPPE in chloroform (10 mg/mL)
  2. Create thin film via rotary evaporation
  3. Hydrate with PBS buffer (pH 7.4)

Case 2: Cell Membrane Mimetics

DPPE enables creation of stable:

  • Supported lipid bilayers for biosensors
  • Membrane raft studies

4. Customer Success Stories

4.1 Merck KGaA

Challenge: Required stable liposomes for antibody conjugation
Solution: DPPE-based formulations showed 92% encapsulation efficiency
Result: 40% improvement in shelf-life stability

4.2 Avanti Polar Lipids

Utilized DPPE in:
– Custom membrane protein studies
– Achieved 2.8Å resolution in cryo-EM analysis

5. Request a Quote

Contact our technical team for:

  • Bulk pricing (10g-100kg quantities)
  • GMP-grade specifications
  • Custom lipid formulation services

Email: info@vivalr.com
Tel: (86) 15866781826

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