5-Bromo-2-chloronicotinic acid

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5-Bromo-2-chloronicotinic Acid: Comprehensive Product Guide

1. Product Overview & Specifications

Basic Information

5-Bromo-2-chloronicotinic acid (CAS 374545-67-8) is a halogenated nicotinic acid derivative widely used in pharmaceutical synthesis. Key parameters:

  • Molecular Formula: C6H3BrClNO2
  • Molecular Weight: 236.45 g/mol
  • Purity: ≥98% (HPLC)
  • Appearance: White to off-white crystalline powder

Comparative Analysis

Parameter 5-Bromo-2-chloronicotinic Acid Similar Compounds
Solubility DMSO, Ethanol Limited in organic solvents
Reactivity High (dual halogen sites) Single reactive site
Thermal Stability Stable up to 250°C Degrades at 200°C

2. Key Applications & Uses

Pharmaceutical Intermediates

Used in synthesizing kinase inhibitors and anticancer agents through:

  • Suzuki-Miyaura cross-coupling reactions
  • Buchwald-Hartwig amination

Agrochemical Development

Critical component in creating novel pesticides with:

  • Enhanced bioactivity against resistant pests
  • Improved environmental stability

3. Usage Case Studies

Case 1: Antiviral Drug Synthesis

Challenge: Develop broad-spectrum antiviral compound
Solution: Utilized as coupling partner in Pd-catalyzed reaction
Result: 72% yield of target molecule with >99% purity

Case 2: OLED Material Production

Challenge: Create electron-transport layer material
Solution: Served as anchoring group in coordination complex
Result: 15% improvement in device efficiency

4. Client Success Stories

PharmaTech Solutions (Germany)

Project: Development of third-generation EGFR inhibitors
Usage: Key intermediate in lead compound optimization
Outcome: Accelerated preclinical development by 8 months

AgroNova Ltd (USA)

Project: Next-generation fungicide formulation
Usage: Central scaffold for bioactive molecule
Outcome: Achieved 94% field efficacy against fungal pathogens

5. Request Customized Solutions

Our technical team specializes in custom synthesis and application development:

  • Bulk quantities available (1kg to ton-scale)
  • GMP-grade manufacturing options
  • Regulatory support for FDA/EMA submissions

Contact our experts:
Email: info@vivalr.com
Tel: (86) 15866781826

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