5-Bromo-2-chloronicotinic Acid: Comprehensive Product Guide
Table of Contents
1. Product Overview & Specifications
Basic Information
5-Bromo-2-chloronicotinic acid (CAS 374545-67-8) is a halogenated nicotinic acid derivative widely used in pharmaceutical synthesis. Key parameters:
- Molecular Formula: C6H3BrClNO2
- Molecular Weight: 236.45 g/mol
- Purity: ≥98% (HPLC)
- Appearance: White to off-white crystalline powder
Comparative Analysis
| Parameter | 5-Bromo-2-chloronicotinic Acid | Similar Compounds |
|---|---|---|
| Solubility | DMSO, Ethanol | Limited in organic solvents |
| Reactivity | High (dual halogen sites) | Single reactive site |
| Thermal Stability | Stable up to 250°C | Degrades at 200°C |
2. Key Applications & Uses
Pharmaceutical Intermediates
Used in synthesizing kinase inhibitors and anticancer agents through:
- Suzuki-Miyaura cross-coupling reactions
- Buchwald-Hartwig amination
Agrochemical Development
Critical component in creating novel pesticides with:
- Enhanced bioactivity against resistant pests
- Improved environmental stability
3. Usage Case Studies
Case 1: Antiviral Drug Synthesis
Challenge: Develop broad-spectrum antiviral compound
Solution: Utilized as coupling partner in Pd-catalyzed reaction
Result: 72% yield of target molecule with >99% purity
Case 2: OLED Material Production
Challenge: Create electron-transport layer material
Solution: Served as anchoring group in coordination complex
Result: 15% improvement in device efficiency
4. Client Success Stories
PharmaTech Solutions (Germany)
Project: Development of third-generation EGFR inhibitors
Usage: Key intermediate in lead compound optimization
Outcome: Accelerated preclinical development by 8 months
AgroNova Ltd (USA)
Project: Next-generation fungicide formulation
Usage: Central scaffold for bioactive molecule
Outcome: Achieved 94% field efficacy against fungal pathogens
5. Request Customized Solutions
Our technical team specializes in custom synthesis and application development:
- Bulk quantities available (1kg to ton-scale)
- GMP-grade manufacturing options
- Regulatory support for FDA/EMA submissions
Contact our experts:
Email: info@vivalr.com
Tel: (86) 15866781826


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