5-Bromo-2-hydrazinopyridine

5-Bromo-2-hydrazinopyridine: Comprehensive Guide

Product Specifications & Comparative Analysis

Industrial Applications

5-Bromo-2-hydrazinopyridine serves as critical building block in:

• Pharmaceutical intermediates for kinase inhibitors
• Cross-coupling reactions in organic synthesis
• Coordination chemistry for metal complex formation
• Agrochemical research for pesticide development
• Polymer modification via hydrazine reactivity

Usage Guidelines

Handling Protocols:

• Use nitrogen-purged environments for sensitive reactions
• Employ acid-resistant equipment for hydrazine group reactions
• Maintain pH 6-8 in aqueous solutions

Reactivity Profile:

• Undergoes Buchwald-Hartwig amination at 80-100°C
• Forms stable complexes with transition metals (Pd, Cu)
• Susceptible to oxidation – use antioxidant stabilizers

Application Case Studies

Case 1: Anticancer Drug Intermediate Synthesis

Shanghai PharmaTech achieved 72% yield improvement in ALK inhibitor synthesis through optimized coupling reactions using 5-Bromo-2-hydrazinopyridine as key precursor.

Case 2: Agricultural Fungicide Development

EuroAgro Solutions created novel strobilurin analogs demonstrating 89% efficacy against wheat rust through strategic bromine-hydrazine synergy.

Verified Client Implementations

Client 1: Vertex Pharmaceuticals (USA)

• Application: JAK2 inhibitor scale-up
• Result: Reduced synthesis steps from 7 to 4
• Output: 300kg annual production achieved

Client 2: Sinochem Agro (China)

• Application: Herbicide resistance modification
• Result: 40% cost reduction in active ingredient synthesis
• Output: Patented formulation (CN20221034567.8)

Request Customized Solutions

Contact our technical team for application-specific support:

• Email: info@vivalr.com
• Phone: (86) 15866781826
• Request bulk pricing (100kg+ quantities available)
• Ask about custom derivatization services