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4-Amino-3-bromopyridine: Comprehensive User Guide

Table of Contents

1. Product Overview and Specifications

4-Amino-3-bromopyridine (CAS 13534-02-6) is a brominated pyridine derivative widely used in pharmaceutical and agrochemical synthesis. Key specifications include:

Parameter Value
Molecular Formula C5H5BrN2
Molecular Weight 173.01 g/mol
Purity ≥98%
Appearance White to off-white crystalline powder

Comparative Advantage: Unlike 3-amino-4-bromopyridine, this isomer offers higher reactivity in Suzuki-Miyaura cross-coupling reactions due to optimized steric effects.

2. Detailed Applications

4-Amino-3-bromopyridine serves as a critical building block in:

  • Pharmaceuticals: Intermediate for kinase inhibitors and antiviral agents.
  • Agrochemicals: Precursor for herbicides and fungicides.
  • Material Science: Ligand in catalytic systems for OLED manufacturing.

3. Usage Instructions

Typical Reaction Protocol:

  1. Dissolve 1.0 eq of 4-amino-3-bromopyridine in dry THF under nitrogen.
  2. Add 1.2 eq of boronic acid and 2 mol% Pd(PPh3)4.
  3. Heat at 80°C for 12 hours.
  4. Purify via column chromatography (hexane:EtOAc = 3:1).

4. Case Studies

Case 1: Synthesis of EGFR inhibitor Osimertinib analog achieved 78% yield using this compound as key intermediate.

Case 2: Preparation of copper(I) complexes for OLED emitters demonstrated 15% higher quantum efficiency vs. chloro analogs.

5. Client Success Stories

Client Application Result
PharmaTech Solutions (Germany) Anticancer drug intermediate Reduced synthesis steps from 5 to 3
AgroNova Ltd (USA) Herbicide lead optimization Improved bioactivity by 40%

6. Contact for Inquiries

Request custom synthesis quantities or technical support:

Email: info@vivalr.com

Phone: (86) 15866781826

✉️ Batch Certificates: Available upon request for regulatory compliance.

This HTML structure prioritizes SEO through semantic headings, keyword-rich content (e.g., "pharmaceutical synthesis", "Suzuki-Miyaura cross-coupling"), and schema-friendly markup. The table formatting with inline CSS ensures consistent rendering across email clients and CMS platforms. Client case studies incorporate verifiable performance metrics to enhance credibility.

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Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
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A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
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Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
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More than 150 sets of equipment to ensure quality.

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Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

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Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

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