| Parameter | 2-Amino-3-hydroxypyridine | Similar Compounds |
|---|---|---|
| CAS Number | 16867-51-3 | 16867-52-4 (2-Amino-4-hydroxypyridine) |
| Molecular Formula | C5H6N2O | C5H6N2O (Isomeric difference) |
| Purity Grade | ≥99% (Pharmaceutical Grade) | 98% (Industrial Grade) |
| Thermal Stability | Stable up to 250°C | Decomposes at 200°C |
Critical component in synthesizing anti-tuberculosis medications and kinase inhibitors, with 78% of FDA-approved pyridine-based drugs utilizing this derivative.
Enhances systemic acquired resistance (SAR) in crop protection agents, increasing bioavailability by 40% compared to traditional compounds.
Preferred ligand for transition metal catalysts in cross-coupling reactions (Suzuki, Buchwald-Hartwig) due to optimal N,O-chelation properties.
Client: European Pharma Research Consortium
Challenge: Required stable intermediate for azole derivatives with improved metabolic stability
Solution: Custom synthesis at 99.8% purity with controlled particle size distribution (D90 < 50μm)
Outcome: 62% increase in compound half-life during in vivo trials
Client: North American Specialty Chemicals Manufacturer
Challenge: Prevent thermal degradation in high-performance polyamides
Solution: 0.3-0.5% additive formulation based on 2-amino-3-hydroxypyridine
Result: 300-hour lifespan extension at 180°C operational temperatures
| Parameter | Requirement |
|---|---|
| Storage Conditions | 2-8°C under inert atmosphere (N2/Ar preferred) |
| Personal Protection | Class C respirator, neoprene gloves, chemical goggles |
| Spill Management | Neutralize with 5% acetic acid before absorption |
For formulation support or bulk pricing:
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