3-Hydroxypyridine-4-carboxaldehyde (CAS 1072-23-9) is a high-purity chemical intermediate widely used in pharmaceutical synthesis, agrochemicals, and materials science. Key parameters:
| Parameter | Specification |
|---|---|
| Molecular Formula | C6H5NO2 |
| Molecular Weight | 123.11 g/mol |
| Purity | ≥98% (HPLC) |
| Appearance | Off-white to pale yellow crystalline powder |
| Storage | 2-8°C, protected from light |
Used as a key intermediate in anticancer drugs (e.g., kinase inhibitors) and antibiotics. Its aldehyde group enables efficient Schiff base formation for ligand coupling.
Facilitates synthesis of metal-organic frameworks (MOFs) and conductive polymers due to its chelating properties.
Essential in creating fungicides and herbicides with enhanced bioactivity and environmental stability.
| Parameter | 3-Hydroxypyridine-4-carboxaldehyde | Pyridine-4-carboxaldehyde | 5-Hydroxypyridine-3-carboxaldehyde |
|---|---|---|---|
| Reactivity | High (dual functional groups) | Moderate | Moderate |
| Solubility | DMSO, Ethanol | Water, Ethanol | DMSO |
| Pharma Applications | ★★★★☆ | ★★★☆☆ | ★★☆☆☆ |
Client: Top 10 Global Pharma Company
Challenge: Low yield (32%) in kinase inhibitor intermediate synthesis.
Solution: Used 3-Hydroxypyridine-4-carboxaldehyde as coupling agent.
Result: Yield increased to 78%, reduced reaction time by 40%.
Client: Advanced Materials Corp
Challenge: Unstable coordination polymers.
Solution: Integrated the compound as a structural linker.
Result: Achieved 99% crystallinity and 20% higher gas adsorption capacity.
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