2-Hydroxy-5-methyl-3-nitropyridine: Comprehensive Technical Guide
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | 2-Hydroxy-5-methyl-3-nitropyridine | Analogous Nitropyridine Derivatives |
|---|---|---|
| CAS Number | 7464-14-4 | 21901-34-8 (5-nitro isomer) |
| Molecular Formula | C6H6N2O3 | C6H5BrN2O3 (brominated variant) |
| Molecular Weight | 154.12 g/mol | 233.02 g/mol (brominated variant) |
| Primary Application | Pharmaceutical intermediate | Agrochemical synthesis |
| Reactivity Profile | Nitration precursor | Halogenation substrate |
2. Functional Applications
2.1 Core Industrial Uses
- Pharmaceutical Intermediate: Critical component in synthesis of kinase inhibitors and antimicrobial agents
- Agrochemical Development: Building block for novel pesticide formulations
- Coordination Chemistry: Ligand precursor for transition metal complexes
2.2 Synthetic Pathways
| Synthetic Route | Starting Material | Yield |
|---|---|---|
| Route 1 | 2-Amino-5-methylpyridine | 63% (optimized conditions) |
| Route 2 | 2-Hydroxy-5-methylpyridine | 55-60% (nitration protocol) |
3. Operational Protocols
3.1 Safety Handling Requirements
- PPE Requirements: Neoprene gloves, ANSI-approved goggles, Type P95 respirator
- Ventilation: Minimum 8 air changes/hour in processing areas
- Spill Management: Neutralize with 5% sodium bicarbonate solution
3.2 Storage Specifications
- Temperature: 2-8°C (long-term storage)
- Container: Amber glass with PTFE-lined caps
- Shelf Life: 24 months unopened under recommended conditions
4. Implementation Case Studies
Case Study A: Pharmaceutical API Synthesis
Application: Key intermediate in JAK2 inhibitor production
Process: Multi-step synthesis involving selective O-alkylation
Outcome: 22% overall yield improvement vs. previous methodology
Case Study B: Specialty Polymer Development
Application: Monomer for conductive polyamides
Process: Electrophilic aromatic substitution reactions
Outcome: Achieved 103 S/cm conductivity at 25°C
5. Client Success Stories
Client 1: European Pharma Research Consortium
Project: Development of next-generation antimalarial compounds
Results: Achieved 98.2% purity in GMP-grade batches
Testimonial: “Critical for our lead optimization phase”
Client 2: Asian Agrochemical Manufacturer
Project: Novel systemic insecticide formulation
Results: 40% reduction in production costs vs. traditional methods
Testimonial: “Revolutionized our synthesis workflow”
Technical Consultation & Ordering
Contact our chemistry experts for custom synthesis projects or bulk orders:
Email: info@vivalr.com
Phone: (86) 15866781826


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