4-Cyano-3-Tetrahydrothiophenone Technical Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | 4-Cyano-3-Tetrahydrothiophenone |
|---|---|
| CAS No. | 16563-14-7 |
| Molecular Formula | C5H5NOS |
| Molecular Weight | 127.1643 g/mol |
| Purity | ≥99% (Pharmaceutical Grade) |
| Packaging | 1kg, 5kg, 25kg, 200kg (Customizable) |
| Storage | 2-8°C in sealed containers |
2. Key Applications
- Pharmaceutical Intermediates: Synthesis of bioactive molecules with sulfur-containing heterocycles
- Agrochemical Production: Building block for crop protection agents
- Material Science: Precursor for functionalized polymers and specialty chemicals
- Organic Synthesis: Thiophene derivative in catalytic reactions
3. Usage Guidelines
Handling Recommendations
- Use PPE (nitrile gloves, safety goggles) in well-ventilated areas
- Store separately from strong oxidizers and acids
- Ground containers during transfer operations
Reaction Optimization
- Typical dosage: 0.5-2.0 molar equivalents
- Compatible with polar aprotic solvents (DMF, DMSO)
- Recommended reaction temperature: 40-80°C
4. Industry Case Studies
Case 1: Antiviral Drug Intermediate
A European pharma company utilized this compound as a key precursor in a 5-step synthesis of neuraminidase inhibitors, achieving 78% overall yield with >99.5% chiral purity.
Case 2: OLED Material Development
Japanese researchers incorporated the cyano-thiophene moiety into electron-transport layers, enhancing device luminance efficiency by 22% compared to traditional materials.
5. Client Success Stories
ABC Pharmaceuticals (Germany)
- Application: Synthesis of kinase inhibitor candidates
- Results: Reduced production costs by 35% through improved cyclization efficiency
- Volume: 850kg/year (GMP-grade)
XYZ Agrochemicals (USA)
- Application: Fungicide intermediate
- Results: Achieved 99.2% reaction conversion in flow chemistry systems
- Volume: 2.5 metric tons/quarter
6. Contact for Technical Inquiry
Request custom synthesis protocols or bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826 (24/7 Technical Support)


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