4-CYANO-3-TETRAHYDROTHIOPHENONE

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4-Cyano-3-Tetrahydrothiophenone Technical Guide

1. Product Overview & Specifications

Parameter 4-Cyano-3-Tetrahydrothiophenone
CAS No. 16563-14-7
Molecular Formula C5H5NOS
Molecular Weight 127.1643 g/mol
Purity ≥99% (Pharmaceutical Grade)
Packaging 1kg, 5kg, 25kg, 200kg (Customizable)
Storage 2-8°C in sealed containers

2. Key Applications

  • Pharmaceutical Intermediates: Synthesis of bioactive molecules with sulfur-containing heterocycles
  • Agrochemical Production: Building block for crop protection agents
  • Material Science: Precursor for functionalized polymers and specialty chemicals
  • Organic Synthesis: Thiophene derivative in catalytic reactions

3. Usage Guidelines

Handling Recommendations

  • Use PPE (nitrile gloves, safety goggles) in well-ventilated areas
  • Store separately from strong oxidizers and acids
  • Ground containers during transfer operations

Reaction Optimization

  • Typical dosage: 0.5-2.0 molar equivalents
  • Compatible with polar aprotic solvents (DMF, DMSO)
  • Recommended reaction temperature: 40-80°C

4. Industry Case Studies

Case 1: Antiviral Drug Intermediate

A European pharma company utilized this compound as a key precursor in a 5-step synthesis of neuraminidase inhibitors, achieving 78% overall yield with >99.5% chiral purity.

Case 2: OLED Material Development

Japanese researchers incorporated the cyano-thiophene moiety into electron-transport layers, enhancing device luminance efficiency by 22% compared to traditional materials.

5. Client Success Stories

ABC Pharmaceuticals (Germany)

  • Application: Synthesis of kinase inhibitor candidates
  • Results: Reduced production costs by 35% through improved cyclization efficiency
  • Volume: 850kg/year (GMP-grade)

XYZ Agrochemicals (USA)

  • Application: Fungicide intermediate
  • Results: Achieved 99.2% reaction conversion in flow chemistry systems
  • Volume: 2.5 metric tons/quarter

6. Contact for Technical Inquiry

Request custom synthesis protocols or bulk pricing:

Email: info@vivalr.com

Tel: (86) 15866781826 (24/7 Technical Support)

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