Chemical Name: Lewis A Antigen
Other Name: Lacto-n-fucopentaose ii, Lea-Lactose; Lea-Lactose; lewis-a-pentasaccharide
CAS No.: 21973-23-9
Molecular Fomula: C32H55NO25
Parameter | Lewis A Antigen | Lewis B Antigen | Lewis X Antigen |
---|---|---|---|
CAS Number | 21973-23-9 | 21973-24-0 | 71210-49-2 |
Molecular Formula | C20H35NO14 | C21H37NO14 | C19H33NO13 |
Purity | ≥98% (HPLC) | ≥95% | ≥97% |
Storage | -20°C (lyophilized) | -20°C | -80°C |
Used to detect elevated levels in pancreatic, gastric, and colorectal cancers.
Critical component in Lewis blood group system characterization.
Essential for ELISA kits targeting epithelial cancers (sensitivity: 0.1 ng/mL).
Dissolve 1 mg in 1 mL PBS (pH 7.4) for 1 hour at 25°C.
Typical working concentration: 10-100 μg/mL depending on application.
University of California study achieved 89% specificity using Lewis A-based ELISA.
Phase I trial showed 40% immune response rate when conjugated to carrier proteins.
Developed CE-marked test kit with 95% concordance to histopathology results.
Reduced lead compound screening time by 60% using Lewis A-coated plates.
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