3-Bromo-1-propanol CAS 627-18-9

Chemical Name: 3-Bromo-1-propanol
Synonyms: 3-Hydroxypropyl bromide; Trimethylene bromohydrin
CAS No.: 627-18-9
Molecular Formula: C3H7BrO
Molecular Weight: 138.99
Appearance: Liquid

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3-Bromo-1-propanol (CAS 627-18-9): Comprehensive User Guide

1. Product Overview & Specifications

3-Bromo-1-propanol (CAS 627-18-9) is a brominated alcohol widely used in organic synthesis. Key parameters:

Parameter Value
Molecular Formula C₃H₇BrO
Molecular Weight 138.99 g/mol
Appearance Colorless to pale yellow liquid
Boiling Point 145-147°C
Density 1.47 g/cm³
Solubility Miscible with organic solvents

Comparative Analysis

Feature 3-Bromo-1-propanol 1-Bromo-2-propanol
Reactivity High alkylation efficiency Moderate nucleophilicity
Applications Pharma intermediates, agrochemicals Limited to specialty polymers

2. Key Applications & Uses

  • Pharmaceutical Intermediates: Synthesis of antiviral/anticancer drugs.
  • Agrochemicals: Production of herbicides and fungicides.
  • Polymer Chemistry: Monomer for functionalized polyesters.
  • Research: Building block in organobromine studies.

3. Step-by-Step Usage Guidelines

  1. Handling: Use PPE (gloves, goggles) in ventilated areas.
  2. Reaction Setup: Add dropwise to stirred substrates at 0-5°C.
  3. Purification: Distill under reduced pressure (40-50°C, 10 mmHg).
  4. Storage: Keep in amber glass at 2-8°C under nitrogen.

4. Practical Use Cases

Case 1: Antiviral Drug Intermediate
Used in a 3-step synthesis of Oseltamivir analogs (yield: 82%, purity >99%).

Case 2: Herbicide Production
Key intermediate in Bromoxynil herbicide manufacturing (scale: 500 kg/batch).

5. Client Success Stories

Client A: Top 10 Indian Pharma Company
Application: Synthesized Doravirine (HIV treatment)
Outcome: 30% cost reduction vs. traditional routes

Client B: EU Agrochemical Leader
Application: Chlorothalonil fungicide production
Scale: 8 MT/month since 2022

6. Request a Quote

Contact us for technical specifications, bulk pricing, and SDS:

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(86) 15866781826

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– ISO 9001-certified production
– 99.5% HPLC purity guaranteed
– Global logistics support

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