Pentaethylene Glycol Monomethyl Ether Cas 23778-52-1

1. Product Overview & Specifications

Pentaethylene Glycol Monomethyl Ether (CAS 23778-52-1) is a polyethylene glycol (PEG) derivative widely used in pharmaceutical research, nanotechnology, and polymer chemistry. Its chemical formula is C₁₁H₂₄O₆ with a molecular weight of 252.30 g/mol.

Comparative Analysis

2. Key Applications

• PROTAC Development: Serves as a hydrophilic linker for targeted protein degradation.
• Drug Delivery Systems: Enhances solubility and bioavailability of hydrophobic APIs.
• Nanotechnology: Functionalizes nanoparticles for biomedical imaging.
• Polymer Chemistry: Modifies surface properties of hydrogels and coatings.

3. Usage Guidelines

PROTAC Synthesis Protocol

1. Dissolve 100 mg in anhydrous DMF (10 mL).
2. Add EDC/HOBt coupling agents at 0°C.
3. React with ligand moiety (1:1.2 molar ratio) for 24 hrs.
4. Purify via HPLC (ACN/water gradient).

4. Case Studies

Nanoparticle Functionalization

Used to create stealth nanoparticles (<100 nm) with 90% drug loading efficiency, achieving sustained release over 72 hours in PBS buffer (pH 7.4).

5. Customer Success Stories

PharmaTech Solutions

Developed oral oncology drugs with 3x improved bioavailability using PEGylated formulations (Batch No. PT-2291).

NanoMaterials Inc.

Created MRI contrast agents with 40% signal enhancement (Project NM-4412).

6. Contact for Technical Support

For bulk orders (>1 kg) or custom PEG derivatives:

Email: info@vivalr.com
Tel: (86) 15866781826