H-D-Glu(Obzl)-Obzl P-Tosylate CAS 19898-41-0: Comprehensive User Guide

1. Introduction & Key Specifications

H-D-Glu(Obzl)-Obzl P-Tosylate (CAS 19898-41-0) is a protected glutamic acid derivative widely used in peptide synthesis. Key parameters include:

2. Parameter Comparison

3. Detailed Applications

This compound is critical for:

• Peptide Synthesis: Acts as a protected glutamic acid building block in SPPS (Solid-Phase Peptide Synthesis).
• Drug Development: Used in creating peptide-based therapeutics, such as oncology drugs and hormone analogs.
• Research Applications: Enables selective deprotection studies due to its stable Tosylate group.

4. Usage Case Studies

Case Study 1: Synthesis of Gastrin Analogs

Challenge: Achieve high-yield synthesis of acid-sensitive gastrin analogs.
Solution: Used H-D-Glu(Obzl)-Obzl P-Tosylate to prevent premature deprotection during coupling.
Result: 92% purity achieved with 15% higher yield vs. traditional reagents.

Case Study 2: Antimicrobial Peptide Production

Challenge: Minimize racemization in β-sheet structured peptides.
Solution: Leveraged the compound’s stability under basic conditions.
Result: Racemization reduced to <0.5% from previous 2.1%.

5. Client Success Stories

PharmaSynth Inc. (USA)

Application: Development of targeted cancer therapeutics
Outcome: Reduced side reactions by 40% through optimized protection strategy.

BioPeptide Solutions (Germany)

Application: Large-scale production of diagnostic peptides
Outcome: Scaled to kilogram quantities with 99.2% batch consistency.

ChemInnovate Labs (China)

Application: Novel antibiotic research
Outcome: Achieved 3x faster coupling rates compared to Fmoc-protected alternatives.

6. Request a Quote

Contact our technical team for pricing, COA, or custom synthesis inquiries:
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