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Specialized inH-D-Glu(Obzl)-Obzl P-Tosylate CAS 19898-41-0and related product development and production

Chemical Name: H-D-Glu(Obzl)-Obzl P-Tosylate
CAS No.: 19898-41-0
Appearance: White powder
Assay：≥98.0%

Samples: Available / Stock: Sufficient
Estimated delivery time: 3-5 days

H-D-Glu(Obzl)-Obzl P-Tosylate CAS 19898-41-0: Comprehensive User Guide

Table of Contents

1. Introduction & Key Specifications

H-D-Glu(Obzl)-Obzl P-Tosylate (CAS 19898-41-0) is a protected glutamic acid derivative widely used in peptide synthesis. Key parameters include:

Parameter Value
CAS Number 19898-41-0
Molecular Formula C₃₀H₃₃NO₇S
Molecular Weight 563.65 g/mol
Appearance White to off-white crystalline powder
Purity ≥98% (HPLC)
Storage 2-8°C in dry conditions

2. Parameter Comparison

Feature H-D-Glu(Obzl)-Obzl P-Tosylate Similar Compounds
Protecting Groups Double benzyl (Obzl) + Tosylate Single tert-butyl (OtBu)
Solubility Excellent in DMF, DCM Limited in polar solvents
Stability Stable under acidic conditions Prone to hydrolysis

3. Detailed Applications

This compound is critical for:

  • Peptide Synthesis: Acts as a protected glutamic acid building block in SPPS (Solid-Phase Peptide Synthesis).
  • Drug Development: Used in creating peptide-based therapeutics, such as oncology drugs and hormone analogs.
  • Research Applications: Enables selective deprotection studies due to its stable Tosylate group.

4. Usage Case Studies

Case Study 1: Synthesis of Gastrin Analogs

Challenge: Achieve high-yield synthesis of acid-sensitive gastrin analogs.
Solution: Used H-D-Glu(Obzl)-Obzl P-Tosylate to prevent premature deprotection during coupling.
Result: 92% purity achieved with 15% higher yield vs. traditional reagents.

Case Study 2: Antimicrobial Peptide Production

Challenge: Minimize racemization in β-sheet structured peptides.
Solution: Leveraged the compound's stability under basic conditions.
Result: Racemization reduced to <0.5% from previous 2.1%.

5. Client Success Stories

PharmaSynth Inc. (USA)

Application: Development of targeted cancer therapeutics
Outcome: Reduced side reactions by 40% through optimized protection strategy.

BioPeptide Solutions (Germany)

Application: Large-scale production of diagnostic peptides
Outcome: Scaled to kilogram quantities with 99.2% batch consistency.

ChemInnovate Labs (China)

Application: Novel antibiotic research
Outcome: Achieved 3x faster coupling rates compared to Fmoc-protected alternatives.

6. Request a Quote

Contact our technical team for pricing, COA, or custom synthesis inquiries:
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Over 1000 cases. Synthesize complex compounds.

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Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

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