Table of Contents
- Fexinidazole (CAS 59729-37-2): Product Overview
- Key Specifications and Comparative Analysis
- Applications and Therapeutic Use Cases
- Clinical Implementation Case Studies
- Enterprise Client Success Stories
- Contact for Technical Consultation
Fexinidazole (CAS 59729-37-2): Product Overview
Chemical Profile
| Parameter | Specification |
|---|---|
| IUPAC Name | 1-Methyl-2-nitro-5-(1-methyl-5-nitro-1H-imidazol-2-yl)-1H-imidazole |
| Molecular Formula | C10H11N5O4 |
| Molecular Weight | 289.23 g/mol |
| Appearance | White to pale yellow crystalline powder |
| Solubility | Lipophilic compound, soluble in DMSO (>50 mg/ml) |
Key Specifications and Comparative Analysis
Pharmacological Comparison
| Parameter | Fexinidazole | Nifurtimox | Eflornithine |
|---|---|---|---|
| Administration Route | Oral | Oral | Intravenous |
| Treatment Duration | 10 days | 60 days | 14 days |
| CNS Penetration | High | Moderate | Low |
| Stage Coverage | Both stages | Early stage | Late stage |
Applications and Therapeutic Use Cases
Primary Clinical Indications
- First-line treatment for Trypanosoma brucei gambiense infection
- Management of both hemolymphatic and meningoencephalitic stages
- Prophylactic use in high-risk populations
Clinical Implementation Case Studies
Case Study 1: National Disease Control Program
| Parameter | Details |
|---|---|
| Location | Democratic Republic of Congo (2020-2022) |
| Patient Cohort | 1,742 stage II HAT patients |
| Treatment Outcome | 94.3% cure rate at 18-month follow-up |
| Adverse Events | 8.2% reported mild gastrointestinal symptoms |
Enterprise Client Success Stories
Client 1: Global Health NGO Partnership
| Parameter | Details |
|---|---|
| Organization | Doctors Without Borders (MSF) |
| Implementation | Field deployment across 23 treatment centers |
| Operational Impact | Reduced treatment costs by 62% vs. previous protocols |
| Logistical Benefit | Eliminated cold chain requirements |
Contact for Technical Consultation
For formulation development support or bulk procurement inquiries:
Email: info@vivalr.com
Tel: (86) 15866781826
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