Table of Contents
- Product Overview
- Specifications & Comparison
- Key Applications
- Usage Guidelines
- Industry Case Studies
- Contact for Quotation
Protocatechuic Acid (CAS 99-50-3) Overview
| Parameter | Description |
|---|---|
| Chemical Name | 3,4-Dihydroxybenzoic acid |
| CAS Number | 99-50-3 |
| Molecular Formula | C7H6O4 |
| Molecular Weight | 154.12 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 200-203°C (dec.) |
| Solubility | Soluble in ethanol, DMSO; slightly soluble in water |
Technical Specifications Comparison
| Feature | Protocatechuic Acid | Gallic Acid | Vanillic Acid |
|---|---|---|---|
| Antioxidant Capacity | High | Very High | Moderate |
| Bioavailability | 85-92% | 75-80% | 90-95% |
| Thermal Stability | Stable up to 200°C | Stable up to 250°C | Stable up to 180°C |
| Pharmaceutical Applications | Anti-inflammatory, Antimicrobial | Astringent, Anticancer | Neuroprotective |
Industrial Applications
Pharmaceutical Industry
Used as intermediate in synthesis of cardiovascular drugs and antimicrobial agents. Demonstrates significant radical scavenging activity (IC50 = 8.3 μM in DPPH assay).
Food Preservation
Extends shelf-life of meat products by 40-60% through lipid oxidation inhibition. FDA-approved as GRAS substance (21 CFR 182.60).
Cosmetic Formulations
Effective in anti-aging creams (reduces MMP-1 production by 62% at 50μM concentration) and acne treatments (MIC = 128μg/mL against C. acnes).
Usage Recommendations
| Application | Concentration Range | Synergistic Agents |
|---|---|---|
| Oral Supplements | 50-200 mg/day | Vitamin C, Quercetin |
| Topical Formulations | 0.5-2% w/w | Hyaluronic Acid, Retinol |
| Food Additive | 0.01-0.1% | Rosmarinic Acid, EDTA |
Documented Case Studies
Case 1: Pharmaceutical Intermediate Production
Client: Top 10 Global Pharma Company
Application: Synthesis of antihypertensive drug intermediate
Result: 22% yield improvement vs traditional methods, 99.8% HPLC purity
Case 2: Natural Preservative Development
Client: Organic Food Manufacturer (EU)
Application: Replacement of synthetic BHA in snack products
Result: 18-month shelf life achieved with 0.05% concentration
Case 3: Cosmetic Active Ingredient
Client: Premium Skincare Brand
Application: Anti-pollution serum formulation
Result: 31% reduction in urban dust-induced ROS generation
Request Customized Solution
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Why Choose Our Protocatechuic Acid?
- ≥99.5% HPLC purity guaranteed
- ISO 9001 & Kosher certified production
- Custom particle size distribution (10-200μm)
- Global logistics support (DDP terms available)
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