(S)-4-Chloro-3-hydroxybutyronitrile CAS 127913-44-4

Product Guide: (S)-4-Chloro-3-hydroxybutyronitrile (CAS 127913-44-4)

Table of Contents

• 1. Product Specifications & Comparative Analysis
• 2. Key Applications in Pharmaceutical Synthesis
• 3. Operational Guidelines & Safety Protocols
• 4. Industry Case Studies
• 5. Client Success Stories
• 6. Request Customized Quotation

1. Product Specifications & Comparative Analysis

2. Key Applications in Pharmaceutical Synthesis

As a chiral intermediate, this compound is critical for:

• Rosuvastatin Production: Core precursor in synthesizing the hypolipidemic agent
• Atorvastatin Calcium Synthesis: Key intermediate for Pfizer’s blockbuster drug (Lipitor®)
• Chiral Resolution: Effective resolving agent in stereoselective syntheses

3. Operational Guidelines & Safety Protocols

• Storage: Maintain under inert gas (N₂) at 2-8°C in sealed containers
• Handling: Use PPE including nitrile gloves and chemical goggles
• Incompatibilities: Avoid strong oxidizers and alkaline substances

4. Industry Case Studies

Case 1: Large-Scale Atorvastatin Production

A top-10 pharmaceutical manufacturer achieved 18% yield improvement through optimized reaction conditions using our material (purity: 99.2%, optical rotation: -16.5°).

Case 2: Generic Drug Development

European API producer reduced chiral impurities from 1.8% to 0.3% using our GMP-grade product in rosuvastatin synthesis.

5. Client Success Stories

Wuhan Jiyesheng Chemical Co., Ltd.

“Consistent batch-to-batch quality since 2003 with on-time delivery rate exceeding 98%.”

Yueyang Jiacheng Biotechnology

“Enabled cost reduction of 22% in intermediate production through technical collaboration.”

Changsha Zhensheng Bio-Tech

“Supported our FDA filing with comprehensive analytical documentation and regulatory support.”

6. Request Customized Quotation

Contact our technical sales team for:

• Batch-specific COA
• Custom packaging (25kg fluorinated bottles standard)
• Regulatory support documentation

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