Gamma-cyclodextrin CAS 17465-86-0

Chemical Name: Gamma-cyclodextrin
CAS: 17465-86-0
Sample: available
Assay: 99%

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Gamma-Cyclodextrin (CAS 17465-86-0) Buyer’s Guide

Table of Contents

1. Product Specifications & Comparative Analysis

Parameter Gamma-Cyclodextrin Alpha-Cyclodextrin Beta-Cyclodextrin
CAS Number 17465-86-0 10016-20-3 7585-39-9
Glucose Units 8 6 7
Cavity Diameter (Å) 9.5-10.5 4.7-5.3 6.0-6.5
Solubility in Water (g/100mL, 25°C) 18.5 14.5 1.85
Thermal Stability (°C) Up to 260 Up to 250 Up to 200

Key differentiator: Gamma-cyclodextrin’s larger cavity enables encapsulation of bulkier molecules compared to other variants, while maintaining superior water solubility.

2. Applications in Key Industries

Pharmaceutical Sector

  • Drug solubility enhancement for BCS Class II/IV compounds
  • Ocular drug delivery systems
  • Protein stabilization in biologics

Food Technology

  • Flavor encapsulation in instant beverages
  • Cholesterol reduction in dairy products
  • Preservative stabilization in baked goods

Cosmetic Engineering

  • Fragrance time-release systems
  • Active ingredient protection in anti-aging creams
  • Solubilization of CBD in topical products

3. Operational Guidelines

Dosage Optimization

Application Recommended Ratio Complexation Method
Oral Drug Formulations 1:1 to 1:3 (API:γ-CD) Kneading/Co-evaporation
Topical Preparations 2%-15% w/w Solution Complexation

Storage Protocols

  • Store in airtight containers with desiccant
  • Maintain temperature below 30°C
  • Protect from direct sunlight

4. Industry Case Studies

Pharma: Insoluble Drug Formulation

A European pharma company increased the bioavailability of their antifungal compound from 12% to 89% using γ-CD complexation, reducing required dosage by 60%.

Food: Low-Cholesterol Dairy

Major dairy producer achieved 92% cholesterol reduction in cream products through γ-CD complexation while maintaining texture profile.

5. Client Success Stories

Case 1: Nutraceutical Manufacturer (Germany)

  • Challenge: Curcumin oxidation in softgel capsules
  • Solution: γ-CD encapsulation at 1:2.5 ratio
  • Result: 18-month stability at 40°C/75% RH

Case 2: Topical Analgesic Producer (USA)

  • Challenge: CBD crystallization in cream base
  • Solution: 8% γ-CD aqueous complex
  • Result: Stable emulsion with 95% transdermal absorption

6. Supplier Consultation

Request product specifications or discuss custom complexation solutions:

Email: info@vivalr.com
Phone: (86) 15866781826

Technical support available for:

  • Formulation optimization
  • Regulatory compliance guidance
  • Bulk order customization
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