Gamma-Cyclodextrin (CAS 17465-86-0) Buyer’s Guide
Table of Contents
- Product Specifications & Comparative Analysis
- Applications in Key Industries
- Operational Guidelines
- Industry Case Studies
- Client Success Stories
- Supplier Consultation
1. Product Specifications & Comparative Analysis
| Parameter | Gamma-Cyclodextrin | Alpha-Cyclodextrin | Beta-Cyclodextrin |
|---|---|---|---|
| CAS Number | 17465-86-0 | 10016-20-3 | 7585-39-9 |
| Glucose Units | 8 | 6 | 7 |
| Cavity Diameter (Å) | 9.5-10.5 | 4.7-5.3 | 6.0-6.5 |
| Solubility in Water (g/100mL, 25°C) | 18.5 | 14.5 | 1.85 |
| Thermal Stability (°C) | Up to 260 | Up to 250 | Up to 200 |
Key differentiator: Gamma-cyclodextrin’s larger cavity enables encapsulation of bulkier molecules compared to other variants, while maintaining superior water solubility.
2. Applications in Key Industries
Pharmaceutical Sector
- Drug solubility enhancement for BCS Class II/IV compounds
- Ocular drug delivery systems
- Protein stabilization in biologics
Food Technology
- Flavor encapsulation in instant beverages
- Cholesterol reduction in dairy products
- Preservative stabilization in baked goods
Cosmetic Engineering
- Fragrance time-release systems
- Active ingredient protection in anti-aging creams
- Solubilization of CBD in topical products
3. Operational Guidelines
Dosage Optimization
| Application | Recommended Ratio | Complexation Method |
|---|---|---|
| Oral Drug Formulations | 1:1 to 1:3 (API:γ-CD) | Kneading/Co-evaporation |
| Topical Preparations | 2%-15% w/w | Solution Complexation |
Storage Protocols
- Store in airtight containers with desiccant
- Maintain temperature below 30°C
- Protect from direct sunlight
4. Industry Case Studies
Pharma: Insoluble Drug Formulation
A European pharma company increased the bioavailability of their antifungal compound from 12% to 89% using γ-CD complexation, reducing required dosage by 60%.
Food: Low-Cholesterol Dairy
Major dairy producer achieved 92% cholesterol reduction in cream products through γ-CD complexation while maintaining texture profile.
5. Client Success Stories
Case 1: Nutraceutical Manufacturer (Germany)
- Challenge: Curcumin oxidation in softgel capsules
- Solution: γ-CD encapsulation at 1:2.5 ratio
- Result: 18-month stability at 40°C/75% RH
Case 2: Topical Analgesic Producer (USA)
- Challenge: CBD crystallization in cream base
- Solution: 8% γ-CD aqueous complex
- Result: Stable emulsion with 95% transdermal absorption
6. Supplier Consultation
Request product specifications or discuss custom complexation solutions:
Email: info@vivalr.com
Phone: (86) 15866781826
Technical support available for:
- Formulation optimization
- Regulatory compliance guidance
- Bulk order customization



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