6,6-dimethyl-3-azabicyclo[3.1.0]hexane CAS 943516-54-9

6,6-Dimethyl-3-azabicyclo[3.1.0]hexane (CAS 943516-54-9) Comprehensive Guide

Contents

1. Product Specifications & Comparative Analysis

2. Detailed Applications

Pharmaceutical Intermediate

Critical building block for neuroactive compounds and kinase inhibitors. Particularly effective in:

• Serotonin-norepinephrine reuptake inhibitor (SNRI) development
• Dopamine receptor modulators
• Antidepressant API synthesis

Catalytic Applications

Superior ligand in asymmetric catalysis:

• Enantioselective hydrogenation reactions
• Cross-coupling reactions (Buchwald-Hartwig amination)
• Organocatalytic processes

3. Usage Scenarios

Scenario 1: Antidepressant Synthesis

Optimal dosage: 0.5-1.2 molar equivalents
Reaction time: 4-8 hours at 60°C
Yield improvement: 22-35% vs traditional intermediates

Scenario 2: Catalytic Hydrogenation

Recommended conditions:
– Catalyst loading: 0.8-1.5 mol%
– Pressure: 50-80 psi H₂
– Enantiomeric excess: Up to 92%

4. Industry Case Studies

Case A: Pharmaceutical API Scale-Up

Client: European Pharma Co.
Challenge: Improve yield in SNRI intermediate step
Solution: Implemented CAS 943516-54-9 at 0.8 eq
Results: 28% yield increase, 99.2% purity

Case B: Specialty Chemical Production

Client: US Chemical Manufacturer
Application: Chiral amine synthesis
Outcome: Reduced reaction time from 18h to 6h
Annual savings: $420,000

5. Client Success Stories

PharmaTech Innovations (Germany)

“Using CAS 943516-54-9 reduced our synthesis steps from 5 to 3 in key intermediate production, cutting manufacturing costs by 40% while maintaining exceptional enantiomeric purity.”

Catalysis Solutions Ltd. (USA)

“The bicyclic amine structure demonstrates remarkable thermal stability in continuous flow reactions, enabling 24/7 production cycles without catalyst degradation.”

6. Technical Consultation & Quotation

For batch-specific COA, custom synthesis requirements, or technical documentation:

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