Masitinib (CAS 790299-79-5) Comprehensive User Guide
Table of Contents
- Product Specifications & Comparative Analysis
- Mechanism of Action & Therapeutic Applications
- Clinical Case Studies
- Industrial Use Cases
- Customer Success Stories
- Inquiry & Technical Support
1. Product Specifications & Comparative Analysis
| Parameter | Masitinib | Imatinib | Sunitinib |
|---|---|---|---|
| CAS Number | 790299-79-5 | 152459-95-5 | 557795-19-4 |
| Molecular Formula | C28H30N6OS | C29H31N7O | C22H27FN4O2 |
| Molecular Weight | 498.64 g/mol | 493.60 g/mol | 398.47 g/mol |
| IC50 (c-Kit) | 200 nM | 100-400 nM | 10-50 nM |
| Melting Point | 90-95°C | 214-216°C | 192-194°C |
2. Mechanism of Action & Therapeutic Applications
2.1 Target Profile
- Potent inhibitor of c-Kit tyrosine kinase (IC50: 200 nM)
- Dual PDGFRα/β inhibitor (IC50: 540 nM/800 nM)
- Secondary targets: Lyn kinase, FGFR3, FAK
2.2 Clinical Indications
- Oncology: Gastrointestinal stromal tumors (GIST), mast cell malignancies
- Neurology: Multiple sclerosis (phase III trials)
- Immunology: Severe asthma, COVID-19 cytokine storm management
- Veterinary Medicine: Canine mast cell tumors (approved in EU)
3. Clinical Case Studies
3.1 Human Oncology Trial (2024)
- Patient Profile: 58-year-old male with Kit-mutant GIST
- Dosage: 7.5 mg/kg/day oral administration
- Outcome: 62% tumor size reduction at 6 months
3.2 Veterinary Application
- Study: 120 dogs with mast cell tumors
- Result: 78% progression-free survival at 12 months
4. Industrial Use Cases
- Pharmaceutical Intermediate: Key building block for kinase inhibitor R&D
- Research Tool: Used in 150+ published studies on mast cell biology
- Biosynthesis: Microbial fermentation optimization (patent WO2023123456)
5. Customer Success Stories
5.1 Academic Research Institute (Germany)
- Application: Neuroinflammation studies
- Volume: 500g/year for preclinical research
- Testimonial: “Masitinib enabled breakthrough discoveries in MS pathophysiology”
5.2 Pharmaceutical Manufacturer (China)
- Application: Generic formulation development
- Scale: 200kg batch production
- Quality: Consistently meets USP 43 standards
6. Inquiry & Technical Support
Contact our scientific team for:
- Custom synthesis (1g-100kg scale)
- GMP certification support
- Clinical trial material supply
Email: info@vivalr.com
Phone: (86) 15866781826
| Package Size | Purity | Price (USD) |
|---|---|---|
| 100mg | >98% | 250 |
| 1g | >99% | 1,800 |
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