Comprehensive Guide to Sodium Methylparaben (CAS 5026-62-0)
Table of Contents
- Product Overview & Technical Specifications
- Applications Across Industries
- Usage Guidelines & Best Practices
- Case Studies: Real-World Implementations
- Comparative Analysis with Alternative Preservatives
- Regulatory Compliance & Safety Considerations
- Supplier Selection & Inquiry Guidance
1. Product Overview & Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 5026-62-0 |
| Molecular Formula | C8H7NaO3 |
| Molecular Weight | 174.13 g/mol |
| Appearance | White hygroscopic powder |
| Solubility | Water: 500 g/L (20°C); Ethanol: Slightly soluble |
| pH (1% solution) | 9.7-10.3 |
| Purity (Pharmaceutical Grade) | 98.0%-102.0% (BP/USP standards) |
2. Applications Across Industries
Pharmaceuticals
• Preservative in injectables, ophthalmic solutions, and topical formulations
• Equipment sterilization agent in medical device manufacturing
Food & Beverage
• Dairy products: Extends shelf life by 30-40% in optimal concentrations (0.03-0.06%)
• Carbonated beverages: Effective against yeast at pH 3-5
Cosmetics
• Primary preservative in water-based formulations (lotions, creams)
• Synergistic effect when combined with phenoxyethanol (1:4 ratio)
3. Usage Guidelines & Best Practices
| Application | Recommended Concentration | Temperature Range |
|---|---|---|
| Pharmaceutical Solutions | 0.1-0.3% w/v | 4-40°C |
| Food Preservation | 0.03-0.1% w/w | -20°C to 60°C |
| Cosmetic Formulations | 0.2-0.8% w/w | RT to 45°C |
4. Case Studies: Real-World Implementations
Case 1: Pharmaceutical Manufacturer (Shanxi Jinyang Pharmaceutical Excipients)
• Challenge: Microbial contamination in ophthalmic solution production
• Solution: 0.25% sodium methylparaben in buffer system
• Outcome: 18-month shelf life achieved with compendial compliance
Case 2: Dairy Processor (East China Cooperative)
• Challenge: Post-pasteurization yeast growth in flavored milk
• Solution: 0.05% sodium methylparaben + modified atmosphere packaging
• Outcome: Microbial counts maintained below 102 CFU/mL for 90 days
5. Comparative Analysis
| Preservative | pH Range | Cost Efficiency | Spectrum |
|---|---|---|---|
| Sodium Methylparaben | 3-8 | $$ | Gram+/Fungi |
| Sodium Benzoate | 2.5-4.5 | $ | Yeast/Mold |
| Potassium Sorbate | <5.5 | $$ | Broad |
6. Regulatory Compliance
• EU Cosmetic Regulation (EC) No 1223/2009: Max 0.4% single/0.8% total paraben content
• FDA 21 CFR 184.1490: GRAS status for food applications
• China GB 2760-2014: Approved for 16 food categories
7. Supplier Evaluation & Contact
Key selection criteria:
1. Certification: ISO 9001, GMP compliance
2. Batch-to-batch consistency (RSD <1.5%)
3. Technical support for formulation optimization
Contact our preservation experts:
Email: info@vivalr.com
Tel: (86) 15866781826
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