Cholesterol Cas 57-88-5

Chemical Name:Cholesterol
CAS: 57-88-5
Molecular Fomula:C27H46O
Molecular Weight: 386.65
Appearance: White or similar sheet crystal
Purity: 99.2%
 
related documents:

COA of Cholesterol cas 57-88-5
TDS of Cholesterol cas 57-88-5

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Cholesterol (CAS 57-88-5): Comprehensive Technical Guide

1. Chemical and Physical Properties

Property Value
CAS Number 57-88-5
Molecular Formula C27H46O
Molecular Weight 386.65 g/mol
Melting Point 148–150°C
Boiling Point 360°C
Solubility Negligible in water; soluble in organic solvents (e.g., ethanol, chloroform)
Storage 2–8°C (dry, protected from light)

Purity Grades: Available in technical (95%) and research-grade (≥98%) forms, with custom purity options for specialized applications.

2. Biological Functions and Applications

Key Roles in Biology:

  • Cell Membrane Stability: Regulates fluidity and permeability of eukaryotic cell membranes.
  • Precursor for Synthesis: Essential for producing steroid hormones (e.g., cortisol, estrogen), vitamin D3, and bile acids.
  • Lipid Raft Formation: Facilitates cellular signaling and protein sorting.

Industrial and Research Applications:

  • Drug Delivery Systems: Integral component of liposomes and lipid nanoparticles for targeted therapeutics.
  • Biomaterials: Used in coatings for medical devices to enhance biocompatibility.
  • Diagnostics: Standard reference material for lipid profiling in clinical assays.
  • Cosmetics: Stabilizes emulsions in skincare formulations.

3. Industrial and Research Use Cases

Case 1: Liposome Production

Application: Cholesterol is blended with phospholipids (e.g., DOPC, DSPC) to create stable liposomal carriers for mRNA vaccines, achieving >90% encapsulation efficiency.

Case 2: Hormone Synthesis

Application: Serves as the starting material for industrial-scale synthesis of cortisone and testosterone derivatives via enzymatic modification.

4. Client Case Studies

Client A: Xi’an Qiyue Biology

Usage: Procured 500 kg of cholesterol (98% purity) annually for lipid nanoparticle (LNP) production. Achieved 30% reduction in manufacturing costs through optimized formulation protocols.

Client B: Shaanxi Xingbei Aike Biotechnology

Usage: Integrated cholesterol into PEGylated nanocarriers for oncology drug delivery, improving tumor targeting efficiency by 40% in preclinical trials.

Client C: Zhengzhou Alpha Chemical

Usage: Supplies research-grade cholesterol to academic institutions for membrane protein studies, cited in 15+ peer-reviewed publications.

5. Quality Standards and Ordering Information

Quality Assurance:

  • HPLC-validated purity (95–99%)
  • ISO 9001-certified manufacturing
  • Batch-specific COA provided

Packaging Options:

  • Research-scale: 1 g to 1 kg (vials or glass bottles)
  • Bulk orders: 25 kg drums with desiccant

Contact for Quotation:

Email: info@vivalr.com
Tel: (86) 15866781826

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