4-Iodobenzoic Acid (CAS 619-58-9): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
4-Iodobenzoic Acid (CAS 619-58-9) is a halogenated benzoic acid derivative widely used in organic synthesis and pharmaceutical research. Key parameters include:
| Parameter | Specification | Comparison with Analogues |
|---|---|---|
| Molecular Formula | C7H5IO2 | Higher molecular weight vs. 4-bromo/chloro derivatives |
| Purity | ≥98% (HPLC) | Similar to pharmaceutical-grade analogues |
| Melting Point | 270-274°C | Higher than 4-fluorobenzoic acid (185°C) |
| Solubility | Soluble in DMSO, DMF; sparingly in water | Comparable to other halogenated benzoic acids |
2. Applications of 4-Iodobenzoic Acid
2.1 Organic Synthesis
Acts as a key intermediate in Suzuki-Miyaura cross-coupling reactions for biaryl compound synthesis.
2.2 Pharmaceutical Development
Used in radiopharmaceuticals and as a building block for anticancer agents targeting tyrosine kinases.
2.3 Material Science
Modifies polymer structures to enhance thermal stability in high-performance materials.
3. Usage Scenarios & Case Studies
3.1 Synthesis of 4-Iodobenzoyl Chloride
Step 1: React 4-iodobenzoic acid (10g) with thionyl chloride (20ml) at 70°C for 3hrs.
Step 2: Purify via vacuum distillation (yield: 92%).
3.2 Radiolabeling for PET Imaging
Used in 123I-labeled diagnostic agents for thyroid imaging with >95% radiochemical purity.
4. Client Success Stories
4.1 PharmaTech Solutions (Germany)
Developed novel kinase inhibitors using 4-iodobenzoic acid as core structure, achieving IC50 values of 12nM in preclinical trials.
4.2 Materials Innovators Corp (USA)
Enhanced polyimide film stability by 40% through 4-iodobenzoic acid side-chain modification for aerospace applications.
5. Request a Quote
Contact our technical team for batch-specific COAs, MSDS, and custom synthesis options:
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