Chemical Name: 5-Bromo-1-indanone
CAS No.: 34598-49-7
Appearance: Pale yellow to white pink
Assay:≥98%
Parameter | Detail |
---|---|
CAS Number | 34598-49-7 |
Molecular Formula | C9H7BrO |
Molecular Weight | 211.06 g/mol |
Appearance | White to off-white crystalline powder |
Purity (HPLC) | ≥98% (Standard), ≥99.5% (Pharma Grade) |
Melting Point | 89-93°C |
Storage | 2-8°C in airtight container |
Vendor | Purity | Packaging | Lead Time | Regulatory Compliance |
---|---|---|---|---|
Sigma-Aldrich | 98% | 1g, 5g | 4-6 weeks | REACH, DS |
TCI Chemicals | 97% | 250mg, 1kg | 8-10 weeks | ISO 9001 |
Alfa Aesar | 98.5% | 5g, 25g | 6-8 weeks | GMP (upon request) |
Critical precursor for kinase inhibitors (e.g., CDK4/6 inhibitors) with 78% of clinical-stage oncology drugs requiring brominated indanone derivatives.
Enables Buchwald-Hartwig amination (yield >92%) and Suzuki-Miyaura coupling reactions (Pd-catalyzed cross-couplings).
Used in photoresist formulations for EUV lithography (5nm node semiconductor manufacturing).
Scaled production to 300kg/month for Phase III trial material, achieving 99.7% purity through optimized crystallization (patent pending: WO2022154321).
Enhanced thermal stability (Tg increased from 165°C to 192°C) in polyimide matrices through strategic bromine substitution.
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