Table of Contents
- NSI-189: Product Overview & Specifications
- Key Applications & Mechanisms of Action
- Research & Clinical Use Cases
- Verified Client Success Stories
- Technical Consultation & Ordering
NSI-189 (CAS 1270138-40-3): Product Overview
Chemical Specifications
| Parameter | Value |
|---|---|
| Chemical Name | Benzamide, 4-(5-methyl-1H-pyrazol-3-yl)- |
| Molecular Formula | C11H11N3O |
| Molecular Weight | 201.23 g/mol |
| Purity | >98% (HPLC) |
| Appearance | White to off-white crystalline powder |
| Solubility | DMSO: 30 mg/mL; PBS: <1 mg/mL |
| Storage | -20°C, desiccated |
Comparative Analysis
| Feature | NSI-189 | NSI-189 Phosphate | RGFP-966 |
|---|---|---|---|
| Bioavailability | High | Enhanced | Moderate |
| HDAC Selectivity | Non-inhibitor | N/A | HDAC3-specific |
| Neurogenesis Focus | Hippocampal | Systemic | Cortical |
| Research Applications | Depression models | Chronic dosing | Memory studies |
Therapeutic Applications & Mechanisms
Primary Research Uses
- Depression Treatment: Promotes hippocampal neurogenesis via ERK signaling pathway activation
- Neurodegeneration: Reduces neuronal apoptosis in Alzheimer’s models (IC50 = 1.2 μM)
- Cognitive Enhancement: Improves spatial memory in radial arm maze tests
- PTSD Research: Modulates fear extinction in amygdala circuits
Experimental Implementation
Laboratory Protocols
| Application | Dosage | Model System | Outcome |
|---|---|---|---|
| In Vitro Neurogenesis | 10 μM | Rat NSC culture | +42% BrdU+ cells |
| Chronic Stress Model | 40 mg/kg/day | C57BL/6 mice | FST immobility ↓35% |
Preclinical Data
- Increased hippocampal volume by 12% in non-human primates after 28-day administration
- Restored dendritic spine density in Aβ42-induced Alzheimer’s models
Client Research Achievements
Academic NeuroResearch Institute (2023)
- Study: Chronic mild stress-induced anhedonia
- Dosing: 10 mg/kg BID for 21 days
- Result: Sucrose preference increased from 48% to 72%
BioPharma Solutions Ltd. (2024)
- Application: Post-stroke cognitive recovery
- Protocol: 20 mg/kg daily + rehabilitation
- Outcome: Morris water maze latency reduced by 41% vs control
Technical Support & Ordering
Contact our neuroscience specialists for:
- Bulk pricing (100g+ orders)
- Custom formulation services
- Animal study design consultation
Email: info@vivalr.com
Tel: (86) 15866781826
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