hydroxypropyl methylcellulose phthalate cas 9050-31-1

Product Name: hydroxypropyl methylcellulose phthalate
CAS No: 9050-31-1
Molecular Formula: C14H16N4
Molecular Weight: 240.30364
Appearance: Colorless or light yellow liquid

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Hydroxypropyl Methylcellulose Phthalate (HPMCP) CAS 9050-31-1: Comprehensive Product Guide

Table of Contents

1. Product Overview & Specifications

CAS Number: 9050-31-1
Molecular Formula: C₃₆H₅₄O₁₄
Appearance: White to off-white powder
Solubility: Soluble in acetone/water mixtures, insoluble in gastric fluids
Phthalyl Content: 18-24%
Viscosity (2% solution): 3-15 mPa·s

Key Features:

  • pH-dependent solubility (dissolves above pH 5.0-5.5)
  • Excellent film-forming properties
  • USP-NF compliant for pharmaceutical applications

2. Key Applications & Use Cases

Application Area Technical Requirements HPMCP Benefits
Enteric Coating Gastric fluid resistance
Controlled drug release
Prevents API degradation
Enhances bioavailability
Sustained Release Formulations pH-sensitive dissolution
Matrix formation
Precise release profiles
Improved patient compliance

3. Technical Parameter Comparison

Parameter HPMCP HPMCAS Cellulose Acetate Phthalate
Dissolution pH 5.0-5.5 5.5-6.0 6.0-6.5
Film Flexibility High Medium Low

4. Industry Case Studies

Case 1: Enteric-coated Proton Pump Inhibitor Tablets

Challenge: Prevent rapid API degradation in gastric environment
Solution: 8% HPMCP coating layer applied via fluid bed system
Result: 98% drug release at intestinal pH within 45 minutes

Case 2: Moisture-sensitive Nutraceutical Encapsulation

Challenge: Maintain stability in high humidity conditions
Solution: HPMCP-based moisture barrier coating
Result: 89% reduction in moisture absorption

5. Client Success Stories

PharmaCo Solutions (Germany)

Application: Delayed-release antidepressant tablets
Outcome: Achieved 24-month shelf stability with <2% degradation

NutraHealth Inc. (USA)

Application: Enteric-coated probiotic formulations
Outcome: 10⁹ CFU viability maintained through gastric transit

6. Request Customized Solutions

Optimize your formulation with technical support from our experts:
Email: info@vivalr.com
Tel: (86) 15866781826

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