Table of Contents
- Product Overview & Specifications
- Comparative Analysis with Other Cyclodextrins
- Key Industrial Applications
- Practical Usage Scenarios
- Client Success Stories (2023-2024)
- Technical Consultation & Sample Request
1. Product Overview & Specifications
2,6-di-O-methyl-beta-cyclodextrin (CAS 51166-71-3)
| Parameter | Specification |
|---|---|
| Molecular Formula | C₅₆H₉₈O₃₅ |
| Molecular Weight | 1331.36 g/mol |
| Appearance | White crystalline powder |
| Solubility | >50 mg/mL in water (25°C) |
| Substitution Degree (DS) | 12.0-14.0 methyl groups |
| Purity (HPLC) | ≥98.5% |
| Residual Solvents | <0.1% (ICH Q3C compliant) |
| Storage | 2-8°C in airtight container |
2. Comparative Analysis with Other Cyclodextrins
| Property | β-CD | 2,6-DM-β-CD | HP-β-CD | RM-β-CD |
|---|---|---|---|---|
| Water Solubility (mg/mL) | 18.5 | 52.3 | >500 | 43.7 |
| Hemolytic Activity | High | Low | Very Low | Moderate |
| Log P | -13.2 | -9.8 | -11.5 | -10.3 |
| FDA Approval Status | Limited | Inhalation Approved | Oral/IV | Topical |
3. Key Industrial Applications
3.1 Pharmaceutical Formulations
Enhances bioavailability of poorly soluble APIs (BCS Class II/IV):
- Inhalation therapies: Reduces mucosal irritation in DPIs
- Ophthalmic solutions: Improves corneal permeability
- Oral solid dosages: Enables direct compression formulations
3.2 Analytical Chemistry
- Chiral separation in HPLC columns (USP resolution >2.5)
- Mass spectrometry sample preparation
3.3 Cosmetic Science
- Vitamin stabilization in anti-aging creams
- Fragrance encapsulation in microemulsions
4. Practical Usage Scenarios
4.1 Drug Solubilization Protocol
Optimal complexation method for 10mg/mL API loading:
- Prepare 20% (w/v) 2,6-DM-β-CD solution
- Maintain pH 6.8±0.2 with phosphate buffer
- Use freeze-drying for solid dispersion
4.2 Chromatographic Applications
Recommended mobile phase conditions:
- Concentration: 15mM in 50:50 ACN/water
- Flow rate: 0.8 mL/min (HPLC), 2.0 mL/min (UPLC)
5. Client Success Stories (2023-2024)
Case 1: European Pharma Innovator
Challenge: Improve pulmonary delivery of antifungal compound (log P 4.2)
Solution: 1:3 molar complex with 2,6-DM-β-CD
Result: 8x increase in FPF (Fine Particle Fraction) to 62%
Case 2: US Biotech Startup
Challenge: Stabilize mRNA vaccine components
Solution: Lyophilized formulation with 10% cyclodextrin
Result: 18-month stability at 2-8°C achieved
6. Technical Consultation & Sample Request
Our cyclodextrin specialists provide:
- Free application feasibility analysis
- GMP-grade sample quantities (10g-1kg)
- Regulatory support for IND submissions
Contact formulation experts:
Email: info@vivalr.com
Tel: (86) 15866781826
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