2-Aminothiophenol (CAS 137-07-5): Technical Overview and Applications
Table of Contents
1. Chemical Profile & Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 137-07-5 |
| Molecular Formula | C6H7NS |
| Molecular Weight | 125.19 g/mol |
| Appearance | Yellow to amber liquid/crystalline solid |
| Melting Point | 23-26°C |
| Boiling Point | 234°C at 760 mmHg |
| Density | 1.17 g/cm³ at 25°C |
| Refractive Index | n20/D 1.642 |
| Flash Point | 79°C (closed cup) |
| Solubility | Insoluble in water, soluble in organic solvents |
2. Industrial Applications
This organosulfur compound serves critical functions in:
- Pharmaceutical Synthesis: Key intermediate for cardiovascular drugs (e.g., antianginal agents) and psychotropic medications
- Dye Manufacturing: Precursor for sulfur-containing dyes and pigments
- Chemical Research: Building block for heterocyclic compounds in organic synthesis
- Polymer Industry: Modifier in specialty polymer production
3. Key Properties & Handling
Chemical Stability
- Air-sensitive (oxidizes in presence of oxygen)
- Thermal decomposition above 234°C releases toxic fumes (SOx, NOx)
Reactivity Profile
- Reacts vigorously with strong oxidizers
- Incompatible with acids, acid anhydrides, and chlorates
4. Production Methodology
Industrial synthesis involves:
- Reaction of o-nitrochlorobenzene with sodium sulfide
- Formation of disulfide intermediate
- Catalytic reduction to final product
Process requires controlled conditions due to exothermic nature and hazardous intermediates.
5. Safety Protocols
Hazard Classification
- Corrosive (Category 1B)
- Acute Toxicity (Oral, Dermal)
- Environmental Hazard (Aquatic Chronic)
Exposure Controls
| Parameter | Requirement |
|---|---|
| PPE | Chemical-resistant gloves, face shield, vapor respirator |
| Ventilation | Explosion-proof local exhaust |
| Storage | Inert atmosphere, <25°C, separate from oxidizers |
6. Commercial Availability
Packaging Specifications
- Standard units: 1kg glass bottles
- Bulk quantities: 200kg sealed drums
Quality Standards
- Purity: ≥99% (HPLC)
- Moisture: ≤0.5% (Karl Fischer)
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