n-cbz-glycine ethyl ester cas 1145-81-9

Table of Contents

• Product Overview & Specifications
• Key Applications
• Usage Scenarios
• Client Case Studies
• Contact for Quotation

N-Cbz-Glycine Ethyl Ester (CAS 1145-81-9): Product Overview & Specifications

Basic Parameters

Comparative Analysis

Key Applications in Pharmaceutical & Peptide Chemistry

Peptide Synthesis

Widely used as an amino-protecting group intermediate in solid-phase peptide synthesis (SPPS) to prevent unwanted side reactions.

Drug Intermediate

Serves as a critical building block in ACE inhibitors and protease inhibitor APIs, enabling selective Cbz deprotection under hydrogenolysis.

Bioconjugation

Facilitates controlled crosslinking in antibody-drug conjugates (ADCs) due to its orthogonal protection compatibility.

Usage Scenarios & Best Practices

Case 1: Large-Scale API Manufacturing

Used in a 500kg batch process for Telmisartan intermediate synthesis, achieving 92% yield with 99.5% chiral purity through optimized ethyl ester cleavage.

Case 2: Research-Grade Peptide Libraries

Enabled parallel synthesis of 1,200+ glycine-containing peptides for oncology target screening when paired with automated Fmoc chemistry platforms.

Client Case Studies

PharmaTech Solutions (Germany)

Challenge: Needed consistent supply of GMP-grade Cbz-protected glycine derivatives for anticoagulant API production.
Solution: Implemented our ISO-certified ethyl ester variant with batch-to-batch NMR certification.
Outcome: Reduced synthesis steps by 3 stages, achieving 18% cost savings over 2 years.

BioSynth Laboratories (USA)

Challenge: Required low-metal (<5ppm) grade for sensitive ADC linker applications.
Solution: Custom purified batches with ICP-MS validated trace metal profile.
Outcome: Enabled successful IND submission for Phase I breast cancer therapeutic.

Contact Our Sales Team for Custom Solutions

Email: info@vivalr.com
Phone: (86) 15866781826

Request bulk pricing, COA documentation, or GMP customization options today.