Table of Contents
- Panobinostat (CAS 404950-80-7) Overview
- Technical Specifications & Comparative Analysis
- Mechanisms & Therapeutic Applications
- Clinical & Research Usage Guidelines
- Verified Client Case Studies (2023-2024)
- Request Customized Quotes/Samples
Panobinostat (CAS 404950-80-7): Key Profile
| Parameter | Detail |
|---|---|
| Chemical Name | Panobinostat (LBH589) |
| CAS Number | 404950-80-7 |
| Molecular Formula | C₂₁H₂₃N₃O₂ |
| Molecular Weight | 349.43 g/mol |
| Purity | ≥98% (HPLC) |
| Storage | -20°C, desiccated |
| Solubility | DMSO: 30 mg/mL; Water: <0.1 mg/mL |
Comparative Analysis: Panobinostat vs. Other HDAC Inhibitors
| Feature | Panobinostat | Vorinostat | Romidepsin |
|---|---|---|---|
| HDAC Class Target | I, II, IV | I, II | I |
| IC50 (nM) | 3-15 | ~100 | ~36 |
| Oral Bioavailability | Yes | Yes | No |
| FDA Approval Status | Multiple Myeloma (2015) | CTCL (2006) | PTCL (2009) |
Mechanistic Insights & Clinical Applications
Primary Mechanism: Panobinostat inhibits histone deacetylases (HDACs), inducing histone hyperacetylation, cell cycle arrest, and apoptosis in malignant cells.
Approved Indications:
- Relapsed/Refractory Multiple Myeloma (combined with bortezomib/dexamethasone)
- Investigational Uses: T-cell lymphoma, breast cancer, neurodegenerative diseases
Recommended Protocols & Handling
Dosage Forms: Oral capsules (10 mg, 20 mg), lyophilized powder for injection
Standard Adult Dose: 20 mg orally 3×/week (weeks 1-2 of 21-day cycle)
Reconstitution: Use sterile water for injection; administer IV over 30 minutes
Documented Client Implementations
Case 1: Novartis Oncology Program (2023)
Application: Combination therapy with carfilzomib in Phase III multiple myeloma trial
Outcome: 18% improvement in progression-free survival vs. control (p<0.01)
Case 2: MD Anderson Cancer Center Research (2024)
Application: Epigenetic modulation in triple-negative breast cancer PDX models
Result: 62% tumor volume reduction at 40 mg/kg dose over 28 days
Contact for Technical & Commercial Consultation
Email: info@vivalr.com
Phone: (86) 15866781826
Request Documentation:
- Certificate of Analysis (CoA)
- GMP Compliance Records
- Stability Testing Data
相关产品
Chemical Name: DL-4-Chlorophenylglycine
Cas No.: 6212-33-5
Molecular Fomula: C8H8ClNO2
Molecular Weight: 185.61
Chemical Name: alpha-Hexylcinnamaldehyde
CAS No.: 101-86-0
Molecular Formula: C15H20O
Molecular Weight: 216.32
Appearance: Yellow Liquid
Chemical Name: STODDARD SOLVENT
CAS No.: 64742-88-7
Appearance: Colorless or Light Yellow Liquid
Chemical Name: Ammonium Iron(II) Sulfate
Synonyms: Diammonium iron bis(sulphate); iron (ii) ammonium sulfate
CAS No.: 10045-89-3
Molecular Formula: FeH5NO4S
Molecular Weight: 170.95
Chemical Name: Zinc citrate
Synonyms: Zinc citrate trihydrate
CAS No.: 546-46-3
Molecular Formula: C6H8O7Zn
Molecular Weight: 257.5
Appearance: White powder
Chemical Name: D-Phenothrin
CAS No.: 26046-85-5
Molecular Formula: C23H26O3
Molecular Weight: 350.45
Appearance: Oil
Chemical Name: D-PANTOTHENIC ACID
CAS No.: 79-83-4
Molecular Formula: C9H17NO5
Molecular Weight: 219.24
Appearance: Colorless or Light Yellow Oily Liquid
Chemical Name: Isoflavone
Synonyms: Soy Isoflavone; Soybean Lsoflavones; 3-Phenylchromen-4-one; 3-Phenylchromone
CAS No.: 574-12-9
Molecular Formula: C15H10O2
Molecular Weight: 222.24
Appearance: Powder
Chemical Name: 1,5-Diphenylcarbazide
Synonyms: 1,5-Diphenylcarbohydrazide; 2,2’-diphenylcarbazide; Diphenylcartazide; sym-diphenylcarbazide
CAS No.: 140-22-7
Molecular Formula: C13H14N4O
Molecular Weight: 242.28
Chemical Name: D-Phenothrin
CAS No.: 26046-85-5
Molecular Formula: C23H26O3
Molecular Weight: 350.45
Appearance: Oil
Chemical Name: Choline salicylate
CAS No.: 2016-36-6
Molecular Formula: C12H19NO4
Molecular Weight: 241.28
Appearance: Red-Brown Crystal
Chemical Name: 1,1,2,2-Tetrachloroethane
Other Name: Tetrachlorethane
CAS No.: 79-34-5
Molecular Formula: C2H2Cl4
Molecular Weight: 167.85
Appearance: Liquid
评论
目前还没有评论。