1-Chloroethyl chloroformate CAS 50893-53-3

1-Chloroethyl Chloroformate (CAS 50893-53-3): Comprehensive Guide

Table of Contents

• Product Overview & Specifications
• Applications & Detailed Uses
• Usage Guidelines & Case Studies
• Client Success Stories
• Inquiry & Contact

1. Product Overview & Specifications

1-Chloroethyl chloroformate (CAS 50893-53-3) is a highly reactive organochlorine compound widely used in organic synthesis. Below are key specifications:

Comparison with Similar Chloroformates

2. Applications & Detailed Uses

Primary Applications:

• Acylating Agent: Introduces acyl groups into amines, alcohols, or thiols.
• Protecting Groups: Temporarily blocks reactive sites (e.g., -NH₂) during multi-step syntheses.
• Pharmaceutical Intermediates: Synthesizes APIs like antihypertensives or antivirals.
• Agrochemicals: Key in producing herbicides and fungicides.

Reaction Mechanisms:

• Forms mixed carbonates with alcohols.
• Generates carbamates with amines.
• Participates in Curtius-type rearrangements.

3. Usage Guidelines & Case Studies

Case Study 1: Peptide Synthesis

Scenario: A research lab synthesized a tripeptide using 1-chloroethyl chloroformate to activate carboxyl groups. The reaction achieved 92% yield under inert conditions (0°C, DCM solvent).

Case Study 2: Drug Intermediate Production

Scenario: A pharmaceutical company utilized the compound to prepare a key intermediate for an anticoagulant drug, reducing reaction steps from 5 to 3.

4. Client Success Stories

Client A: European Pharma Manufacturer

• Challenge: Low yield in API synthesis due to side reactions.
• Solution: Switched to 1-chloroethyl chloroformate for selective acylation.
• Result: Yield increased by 35%, purity >99%.

Client B: Agrochemical Company (USA)

• Challenge: Needed a stable protecting group for amine functionalization.
• Solution: Applied the compound under controlled pH conditions.
• Result: Achieved 98% deprotection efficiency.

5. Inquiry & Contact

Optimize your synthesis with high-purity 1-chloroethyl chloroformate. Our team provides:

• Custom bulk quantities
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• Regulatory documentation (CoA, MSDS)

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