1. Product Overview & Specifications

(-)-Dihydroxybutane-1,4-dioic Acid Diethyl Ester (CAS 13811-71-7) is a chiral building block widely used in asymmetric synthesis. Key parameters:

2. Key Applications

• Chiral auxiliary in pharmaceutical intermediates
• Asymmetric catalysis precursor
• Ligand synthesis for transition metal complexes
• Resolution agent for enantiomer separation

3. Usage Guidelines

1. Store under inert atmosphere (N₂ or Ar)
2. Use anhydrous solvents for reactions
3. Optimal reaction temperature: -20°C to 25°C
4. Recommended catalyst ratio: 1:1.2 (substrate:catalyst)

4. Case Studies

Case 1: Antiviral Drug Intermediate Synthesis

Used as chiral template in Remdesivir analog production:

• Yield improvement: 72% → 89%
• ee value maintained at 97%

Case 2: Asymmetric Hydrogenation

Key component in ruthenium-based catalyst system:

• Turnover number (TON): 15,000
• Selectivity: 99:1 (R:S)

5. Client Success Stories

PharmaTech Inc. (USA)

• Application: Parkinson’s disease drug candidate
• Result: Reduced enantiomer separation costs by 40%

ChemSolutions GmbH (Germany)

• Application: High-performance liquid crystal synthesis
• Result: Achieved 99.3% optical purity in final product

6. Contact for Custom Solutions

Optimize your chiral synthesis workflows with our technical expertise:

info@vivalr.com
(86) 15866781826