1H-1,2,4-Triazole-3-thiol (CAS 3179-31-5) Technical Guide
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | Specification | Industry Standard |
|---|---|---|
| Chemical Name | 1H-1,2,4-Triazole-3-thiol | Triazole derivatives |
| CAS Number | 3179-31-5 | N/A |
| Molecular Formula | C2H3N3S | Varies by compound |
| Molecular Weight | 101.13 g/mol | 80-120 g/mol (typical) |
| Appearance | White to pale yellow crystalline powder | Powder/Crystalline |
| Melting Point | 218-221°C | 200-250°C (triazole derivatives) |
| Solubility | Water & ethanol soluble | Polar solvent soluble |
2. Industrial Applications
Core Functional Uses:
- Pharmaceutical Intermediate: Key precursor in antiviral/anticancer drug synthesis
- Corrosion Inhibition: Effective metal surface treatment agent (0.05-0.2% concentration)
- Photochemical Applications: Photoinitiator in specialty imaging processes
- Polymer Modification: Cross-linking agent for specialty resins
Performance Advantages:
- Thermal stability up to 250°C
- pH tolerance range: 3.5-9.0
- Low environmental persistence (DT50 < 48hrs)
3. Operational Guidelines
Handling Protocol:
- Use NIOSH-approved PPE (N95 respirator, chemical gloves)
- Maintain ambient temperature storage (15-25°C)
- Implement inert atmosphere for high-purity applications
- Maximum working concentration: 5% w/v aqueous solution
Reaction Parameters:
| Application | Optimal Temperature | Reaction Time | Yield Efficiency |
|---|---|---|---|
| Drug Synthesis | 60-80°C | 4-6 hours | 82-89% |
| Corrosion Formulation | RT | 30-45 min | 95%+ |
4. Implementation Case Studies
Case A: Pharmaceutical Manufacturing
Challenge: Improve nucleoside analog synthesis efficiency
Solution: Implemented as coupling agent in step 3
Results: 18% yield improvement, 35% reduction in side products
Case B: Industrial Cooling Systems
Challenge: Copper alloy corrosion in heat exchangers
Solution: 0.1% additive in cooling water treatment
Results: 94% corrosion rate reduction (ASTM D1384)
5. Client Success Stories
Client 1: Specialty Chemical Manufacturer
- Location: Wuhan, China
- Application: High-purity drug intermediates
- Outcome: Achieved 99.7% purity for EU market compliance
Client 2: Metal Treatment Facility
- Location: Guangdong Province
- Application: Automotive component preservation
- Outcome: Extended part lifespan by 3.2x (salt spray test)
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