Voriconazole CAS 137234-62-9: Comprehensive Product Guide
Table of Contents
- 1. Product Overview & Specifications
- 2. Key Applications & Therapeutic Uses
- 3. Clinical Case Studies
- 4. Industry Adoption & Client Success Stories
- 5. Technical Support & Inquiry Guidance
1. Product Overview & Specifications
| Parameter | Voriconazole | Fluconazole | Itraconazole |
|---|---|---|---|
| CAS Number | 137234-62-9 | 86386-73-4 | 84625-61-6 |
| Molecular Formula | C16H14F3N5O | C13H12F2N6O | C35H38Cl2N8O4 |
| Half-Life | 6 hrs | 30 hrs | 21 hrs |
| Bioavailability | 96% | 90% | 55% |
| Antifungal Spectrum | Aspergillus, Candida | Candida only | Broad-spectrum |
2. Key Applications & Therapeutic Uses
Medical Applications
- First-line treatment for invasive aspergillosis (success rate: 52.8% vs amphotericin B’s 31.6%)
- Candidemia in non-neutropenic patients (ICU mortality reduction: 15.2% with voriconazole vs 22.2% standard care)
- Prophylaxis in hematopoietic stem cell transplant recipients
Research Applications
- Antifungal resistance studies (MIC90 values: 0.5-1 μg/ml for Candida albicans)
- Drug interaction research (CYP2C19/CYP3A4 enzyme studies)
3. Clinical Case Studies
Case 1: Pulmonary Aspergillosis
Patient: 58yo male with AML
Regimen: 6 mg/kg IV q12h ×24hrs → 4 mg/kg maintenance
Outcome: Radiological improvement in 72% lesions at 14 days
Case 2: Breakthrough Candidemia
Patient: 34yo post-liver transplant
Regimen: 200mg PO q12h + therapeutic drug monitoring
Outcome: Blood culture negativity achieved in 96 hrs
4. Industry Adoption & Client Success Stories
Client 1: European Pharma Manufacturer
- Annual procurement: 850kg voriconazole API
- Application: Generic VFEND® production
- Batch consistency: 99.92-100.08% potency across 36 lots
Client 2: US Research Hospital
- Usage: Antifungal stewardship program
- Outcome: 41% reduction in azole-resistant Candida cases
- Cost savings: $2.8M/year through optimized dosing protocols
5. Technical Support & Inquiry Guidance
For formulation development support or bulk procurement quotes:
Email: info@vivalr.com
Tel: (86) 15866781826
Why Choose Us?
- ISO 9001-certified manufacturing
- Strict 99.5%+ purity control (ICH Q3D elemental limits)
- Global logistics network (DDU/DDP Incoterms available)

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