Table of Contents
- Product Overview
- Technical Specifications & Comparative Analysis
- Applications of Chloroacetyl Chloride
- Operational Guidelines & Safety Protocols
- Industry Case Studies
- Procurement Strategy & Supplier Evaluation
- Request Quotation/Sample
Chloroacetyl Chloride (CAS 79-04-9): Critical Industrial Intermediate
Chloroacetyl chloride, a reactive acyl chloride with CAS registry number 79-04-9, is extensively utilized in organic synthesis. This colorless to yellowish liquid (molecular weight: 112.94 g/mol) exhibits a boiling point of 105-106°C and density of 1.42 g/cm³ at 25°C.
Technical Specifications & Comparative Analysis
| Parameter | Chloroacetyl Chloride | Acetyl Chloride | Benzoyl Chloride |
|---|---|---|---|
| CAS Number | 79-04-9 | 75-36-5 | 98-88-4 |
| Reactivity | High (dual functional groups) | Moderate | Low |
| Pharma Applications | API intermediates | Acetylation agent | Limited use |
Industrial Applications
Pharmaceutical Manufacturing
Key intermediate in synthesizing:
- Anticancer agents (e.g., Chlorambucil)
- Antibiotics (Cephalosporin derivatives)
- Neurological drugs
Agrochemical Production
Critical for:
- Herbicide precursors (e.g., Alachlor, Butachlor)
- Insect growth regulators
- Fungicide intermediates
Operational & Safety Guidelines
Handling Requirements
- PPE: Chemical-resistant gloves, face shield, vapor respirator
- Storage: Nitrogen atmosphere, < 25°C
- Incompatibilities: Strong bases, oxidizers, moisture
Emergency Protocols
- Spill response: Neutralize with dry sand, collect in chemical containers
- Eye contact: Immediate 15-minute irrigation
- Fire suppression: CO₂, dry chemical
Documented Industry Implementations
Case 1: InnovPharma Co., Ltd. (2023)
Challenge: Scale-up production of Loratadine intermediate
Solution: Optimized chloroacetylation process using 99.5% purity CAC
Outcome: 22% yield improvement, 15% cost reduction
Case 2: AgroGuard Solutions (2024)
Challenge: Develop next-gen herbicide formulation
Solution: CAC-based synthesis of chloroacetamide compounds
Outcome: 40% faster synthesis vs traditional methods
Strategic Procurement Considerations
| Supplier Criteria | Priority Level | Industry Benchmark |
|---|---|---|
| Purity Consistency (≥99.5%) | Critical | ISO 9001 Certification |
| Bulk Handling Capability | High | 2000L reactor capacity |
| Regulatory Compliance | Mandatory | REACH, TSCA, K-REACH |
Request Product Specifications or Quotation
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