chloroacetyl chloride cas 1979-4-9

Chemical Name:Chloroacetyl Chloride
CAS No.: 79-04-9
Molecular Formula: C2H2Cl2O
Molecular Weight: 112.94
Appearance:Colorless transparent liquid

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Table of Contents

Chloroacetyl Chloride (CAS 79-04-9): Critical Industrial Intermediate

Chloroacetyl chloride, a reactive acyl chloride with CAS registry number 79-04-9, is extensively utilized in organic synthesis. This colorless to yellowish liquid (molecular weight: 112.94 g/mol) exhibits a boiling point of 105-106°C and density of 1.42 g/cm³ at 25°C.

Technical Specifications & Comparative Analysis

Parameter Chloroacetyl Chloride Acetyl Chloride Benzoyl Chloride
CAS Number 79-04-9 75-36-5 98-88-4
Reactivity High (dual functional groups) Moderate Low
Pharma Applications API intermediates Acetylation agent Limited use

Industrial Applications

Pharmaceutical Manufacturing

Key intermediate in synthesizing:

  • Anticancer agents (e.g., Chlorambucil)
  • Antibiotics (Cephalosporin derivatives)
  • Neurological drugs

Agrochemical Production

Critical for:

  • Herbicide precursors (e.g., Alachlor, Butachlor)
  • Insect growth regulators
  • Fungicide intermediates

Operational & Safety Guidelines

Handling Requirements

  • PPE: Chemical-resistant gloves, face shield, vapor respirator
  • Storage: Nitrogen atmosphere, < 25°C
  • Incompatibilities: Strong bases, oxidizers, moisture

Emergency Protocols

  • Spill response: Neutralize with dry sand, collect in chemical containers
  • Eye contact: Immediate 15-minute irrigation
  • Fire suppression: CO₂, dry chemical

Documented Industry Implementations

Case 1: InnovPharma Co., Ltd. (2023)

Challenge: Scale-up production of Loratadine intermediate
Solution: Optimized chloroacetylation process using 99.5% purity CAC
Outcome: 22% yield improvement, 15% cost reduction

Case 2: AgroGuard Solutions (2024)

Challenge: Develop next-gen herbicide formulation
Solution: CAC-based synthesis of chloroacetamide compounds
Outcome: 40% faster synthesis vs traditional methods

Strategic Procurement Considerations

Supplier Criteria Priority Level Industry Benchmark
Purity Consistency (≥99.5%) Critical ISO 9001 Certification
Bulk Handling Capability High 2000L reactor capacity
Regulatory Compliance Mandatory REACH, TSCA, K-REACH

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