sulbactam cas 68373-14-8

Chemical Name:Sulbactam
CAS No.: 68373-14-8
Molecular Formula: C8H11NO5S
Molecular Weight:233.24
Appearance:White crystalline powder

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Parameter	Value
CAS Number	68373-14-8
Molecular Formula	C₈H₁₁NO₅S
Molecular Weight	233.24 g/mol
Appearance	White to off-white crystalline powder
Solubility	Freely soluble in water (100 mg/mL)
Storage	2-8°C protected from light
Manufacturer	Entasis Therapeutics (US), CSPC Pharmaceutical (China)

As an irreversible β-lactamase inhibitor, sulbactam:

Inhibits Ambler Class A serine β-lactamases through covalent binding
Enhances antibiotic activity of β-lactams by 4-64 fold against resistant strains
Displays intrinsic bactericidal activity against Acinetobacter baumannii via PBP1/PBP3 inhibition

FDA-approved indications (Xacduro® 2023):

Infection Type	Pathogen Coverage
Hospital-acquired pneumonia	Acinetobacter calcoaceticus-baumannii complex
Ventilator-associated pneumonia	Carbapenem-resistant Acinetobacter spp.

Combination	Ratio	Spectrum
Ampicillin/Sulbactam	2:1	Gram-negative bacilli, anaerobes
Cefoperazone/Sulbactam	1:1	ESBL-producing Enterobacteriaceae
Sulbactam/Durlobactam	2:1	Multidrug-resistant Acinetobacter

Renal Function (CrCl)	Dosing Interval
>45 mL/min	1g q6h
30-44 mL/min	1g q8h
15-29 mL/min	1g q12h
Hemodialysis	Post-dialysis administration required

Case 1: 62-year-old male with VAP caused by CRAB showed 92% clinical cure rate with sulbactam-durlobactam combination therapy (7-day course)
Case 2: ICU outbreak of NDM-1 Klebsiella pneumoniae controlled using cefoperazone/sulbactam 3g q8h (MIC reduction from 32 μg/mL to 2 μg/mL)

Manufacturer	Location	Certifications
Pfizer	USA	USP, cGMP
Qilu Pharmaceutical	China	EDQM, WHO PQ

For formulation support or clinical protocol development:
Email: info@vivalr.com
Tel: (86) 15866781826

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