1. Basic Information & Specifications

2. Key Applications

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a heterocyclic compound with critical roles in biomedical research:

• GTP Cyclohydrolase I Inhibition: Acts as a selective inhibitor of GTPCH-I, the rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis. This property makes it valuable for studying nitric oxide (NO) signaling pathways.
• Inflammatory Response Modulation: Reduces VCAM-1 expression in human umbilical vein endothelial cells (HUVECs) by suppressing NF-κB nuclear translocation.
• Serotonin Regulation: Lowers serotonin levels in murine models, demonstrating utility in neurochemistry studies.
• Antimicrobial Research: Inhibits biopterin-dependent growth in protozoa like Crithidia fasciculata.

3. Research Case Studies

Case Study 1: Macrophage NO Suppression

Objective: Investigate DAHP’s effect on NO production in chicken peritoneal macrophages.
Results: 5 mM DAHP reduced NO levels by 70% within 24 hours through BH4 synthesis inhibition (IC₅₀ = 1.2 μM).

Case Study 2: Vascular Inflammation Model

Objective: Assess VCAM-1 modulation in HUVECs.
Results: 2 mM DAHP decreased VCAM-1 expression by 45% via NF-κB pathway suppression.

4. Client Use Cases

Client 1: Absin Bioscience

• Application: Supplied DAHP (Cat# abs814532) for NO pathway studies
• Specifications: 98% purity, 386–882 USD/100mg
• Storage: -20°C long-term stability

Client 2: Shenzhen HSA Biotech

• Application: Provided analytical standards for HPLC calibration
• Specifications: 5–50 mg batches, COA/NMR/MS documentation

5. Contact for Technical & Commercial Inquiries

For pricing, COA, or custom synthesis requirements:

Email: info@vivalr.com
Tel: (86) 15866781826