Directory
- 1. Basic Information & Specifications
- 2. Applications
- 3. Case Studies
- 4. Usage Guidelines
- 5. Contact for Technical Support
1. Basic Information & Specifications
Product Overview
Chemical Name: 4-Chloro-6-ethyl-5-fluoropyrimidine
CAS Number: 137234-74-3
Molecular Formula: C6H5ClFN2
Molecular Weight: 162.57 g/mol
Key Parameters Comparison
| Parameter | Specification | Analog 1 (5-Fluoropyrimidine) | Analog 2 (6-Chloropyrimidine) |
|---|---|---|---|
| Purity | ≥98% | ≥95% | |
| Melting Point | 89-92°C | 78-80°C | 102-105°C |
| Storage | 2-8°C | Room temperature | 2-8°C |
2. Applications
Pharmaceutical Intermediates
Critical component in synthesizing kinase inhibitors (e.g., EGFR inhibitors) and antiviral agents.
Agrochemicals
Key precursor for fungicides and herbicides requiring fluorinated pyrimidine structures.
Material Science
Building block for photoactive materials in OLED development.
3. Case Studies
Case 1: Oncology Drug Development
Client: European Pharma Company
Usage: Synthesized third-generation EGFR-TKI inhibitors
Result: Achieved 92% yield in palladium-catalyzed cross-coupling reactions
Case 2: Crop Protection Formulation
Client: Asian Agrochemical Manufacturer
Application: Developed broad-spectrum fungicide against Magnaporthe oryzae
Outcome: 40% improvement in field efficacy compared to non-fluorinated analogs
4. Usage Guidelines
Reaction Optimization
Recommended conditions for Suzuki coupling:
- Catalyst: Pd(PPh3)4 (5 mol%)
- Base: K2CO3 (2 eq)
- Solvent: DME/H2O (4:1)
Safety Protocols
| Parameter | Requirement |
|---|---|
| PPE | Nitrile gloves, chemical goggles |
| Ventilation | Fume hood required |
| Spill Management | Absorb with vermiculite, neutralize with 5% acetic acid |
5. Contact for Technical Support
Email: info@vivalr.com
Phone: (86) 15866781826
Request batch-specific COA, custom synthesis protocols, or bulk pricing within 24 hours.
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