Cyclopentyl Methyl Ether (CAS 5614-37-9) Ultimate User Guide
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | CME | THF | Dichloromethane |
|---|---|---|---|
| CAS Number | 5614-37-9 | 109-99-9 | 75-09-2 |
| Molecular Formula | C6H12O | C4H8O | CH2Cl2 |
| Boiling Point | 106°C | 66°C | 39.6°C |
| Flash Point | 11°C | -14°C | -4°C |
| Polarity (ET30) | 38.1 | 37.4 | 41.1 |
Key Advantages: Higher boiling point than THF, lower toxicity vs chlorinated solvents, superior stability in radical reactions.
2. Applications & Industrial Usage
Pharmaceutical Manufacturing
Preferred solvent for:
- Grignard reactions
- Metal-catalyzed cross couplings
- Peptide synthesis
Electronic Chemicals
Critical in:
- Photoresist stripping solutions
- Semiconductor wafer cleaning
- OLED manufacturing
3. Operational Guidelines & Best Practices
Storage Protocols
- Store under nitrogen atmosphere
- Maintain temperature below 25°C
- Use amber glass containers
Reaction Optimization
Recommended concentrations:
| Application | Concentration | Temperature |
|---|---|---|
| Nucleophilic substitutions | 0.5-1.5M | 60-80°C |
| Catalytic hydrogenations | 2.0-3.0M | 25-40°C |
4. Implementation Case Studies
Case 1: API Synthesis Optimization
Challenge: Improve yield in atorvastatin intermediate synthesis
Solution: Replaced dichloromethane with CME in extraction process
Results: Yield increased from 68% → 83%, reduced purification steps
Case 2: Lithium Battery Electrolyte
Objective: Develop non-flammable electrolyte additive
Implementation: 15% CME in EC/DMC electrolyte system
Outcome: 40% reduction in thermal runaway risk
5. Client Success Stories
PharmaCorp Ltd. (Top 10 Global Generic Manufacturer)
Application: Continuous flow synthesis of antihypertensive API
CME Usage: 2.3M solution in Buchwald-Hartwig amination
Benefits Achieved:
– 92% conversion rate (vs 78% with THF)
– 60% reduction in catalyst loading
– 35% lower solvent costs
EcoElectronix (Specialty Electronic Materials)
Challenge: Remove post-etch residues without damaging low-k dielectrics
Solution: CME-based cleaning formulation (Patent pending)
Performance:
– 99.7% residue removal
– Zero dielectric constant change
– Compatible with 3nm node processes
6. Technical Consultation & Inquiry
For technical specifications sheets, custom formulation development, or bulk pricing:
Contact our solvent specialists:
Email: info@vivalr.com
Tel: (86) 15866781826
Submit your requirements for:
– Custom purity grades (99.5%~99.999%)
– Specialty packaging (Drum to ISO tank options)
– Regulatory support (REACH, TSCA, FDA DMF)



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