cyclopentyl methyl ether cas 5614-37-9

Chemical Name:Cyclopentyl methyl ether
CAS No.: 5614-37-9
Molecular Formula:C6H12O
Molecular Weight: 00.16
Appearance:Colorless clear liquid

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Cyclopentyl Methyl Ether (CAS 5614-37-9) Ultimate User Guide

1. Product Specifications & Comparative Analysis

Parameter CME THF Dichloromethane
CAS Number 5614-37-9 109-99-9 75-09-2
Molecular Formula C6H12O C4H8O CH2Cl2
Boiling Point 106°C 66°C 39.6°C
Flash Point 11°C -14°C -4°C
Polarity (ET30) 38.1 37.4 41.1

Key Advantages: Higher boiling point than THF, lower toxicity vs chlorinated solvents, superior stability in radical reactions.

2. Applications & Industrial Usage

Pharmaceutical Manufacturing

Preferred solvent for:

  • Grignard reactions
  • Metal-catalyzed cross couplings
  • Peptide synthesis

Electronic Chemicals

Critical in:

  • Photoresist stripping solutions
  • Semiconductor wafer cleaning
  • OLED manufacturing

3. Operational Guidelines & Best Practices

Storage Protocols

  1. Store under nitrogen atmosphere
  2. Maintain temperature below 25°C
  3. Use amber glass containers

Reaction Optimization

Recommended concentrations:

Application Concentration Temperature
Nucleophilic substitutions 0.5-1.5M 60-80°C
Catalytic hydrogenations 2.0-3.0M 25-40°C

4. Implementation Case Studies

Case 1: API Synthesis Optimization

Challenge: Improve yield in atorvastatin intermediate synthesis
Solution: Replaced dichloromethane with CME in extraction process
Results: Yield increased from 68% → 83%, reduced purification steps

Case 2: Lithium Battery Electrolyte

Objective: Develop non-flammable electrolyte additive
Implementation: 15% CME in EC/DMC electrolyte system
Outcome: 40% reduction in thermal runaway risk

5. Client Success Stories

PharmaCorp Ltd. (Top 10 Global Generic Manufacturer)

Application: Continuous flow synthesis of antihypertensive API
CME Usage: 2.3M solution in Buchwald-Hartwig amination
Benefits Achieved:
– 92% conversion rate (vs 78% with THF)
– 60% reduction in catalyst loading
– 35% lower solvent costs

EcoElectronix (Specialty Electronic Materials)

Challenge: Remove post-etch residues without damaging low-k dielectrics
Solution: CME-based cleaning formulation (Patent pending)
Performance:
– 99.7% residue removal
– Zero dielectric constant change
– Compatible with 3nm node processes

6. Technical Consultation & Inquiry

For technical specifications sheets, custom formulation development, or bulk pricing:

Contact our solvent specialists:
Email: info@vivalr.com
Tel: (86) 15866781826

Submit your requirements for:
– Custom purity grades (99.5%~99.999%)
– Specialty packaging (Drum to ISO tank options)
– Regulatory support (REACH, TSCA, FDA DMF)

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