Comprehensive Guide to (3S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic Acid
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | (3S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic Acid | Competitor A | Competitor B |
|---|---|---|---|
| CAS Number | 1350658-71-1 | 1350658-70-0 | 1350658-72-2 |
| Purity | ≥98.5% (HPLC) | ≥97.0% | ≥95.5% |
| Storage | 2-8°C desiccated | Ambient | 4-10°C |
2. Key Applications in Pharmaceutical Research
This bicyclic β-amino acid derivative serves as critical chiral building block for:
- Protease inhibitor development (HCV NS3/4A, HIV-1)
- Peptidomimetic drug candidates
- Constrained peptide analogs in oncology
3. Operational Protocols & Best Practices
Handling Recommendations:
| Process Stage | Optimal Conditions |
|---|---|
| Coupling Reactions | Use HATU/DIPEA in DMF at 0°C→RT |
| Boc Deprotection | TFA/DCM (4:1) 2hrs @ 0°C |
4. Industry Implementation Case Studies
Case 1: Hepatitis C Drug Development
– Application: Core component in macrocyclic NS3 protease inhibitor
– Outcome: Achieved IC50 of 3.2nM against genotype 1b
5. Verified Client Success Stories
Client A: Top 10 Pharma Company (2024)
– Usage: Synthesized 12 novel kinase inhibitors
– Results: 3 candidates entered preclinical trials
Client B: Biotech Startup (2023)
– Application: Created constrained peptide library
– Achievement: Identified lead compound with 89% target binding
6. Technical Consultation & Ordering Information
Contact our technical team for batch-specific COA and custom synthesis options:
Email: info@vivalr.com
Tel: (86) 15866781826
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