2-Amino-5-bromopyrazine

2-Amino-5-bromopyrazine: Comprehensive Product Guide

Table of Contents

• 1. Product Overview & Specifications
• 2. Applications & Detailed Uses
• 3. Usage Guidelines & Best Practices
• 4. Case Studies
• 5. Client Success Stories
• 6. Request Quotation or Sample

1. Product Overview & Specifications

2-Amino-5-bromopyrazine (CAS 1072-97-5) is a brominated pyrazine derivative widely used in pharmaceutical intermediates and organic synthesis. Key parameters:

2. Applications & Detailed Uses

This compound serves critical roles in:

• Pharmaceutical Synthesis: Key intermediate for kinase inhibitors (e.g., EGFR inhibitors in oncology)
• Agrochemicals: Building block for herbicides with bromine-enhanced bioactivity
• Material Science: Precursor for conductive polymers in flexible electronics
• Research Reagents: Used in Suzuki coupling reactions for cross-coupling studies

3. Usage Guidelines & Best Practices

Handling Protocol:

1. Always use nitrogen atmosphere during reactions to prevent oxidation
2. Recommended solvent: anhydrous DMF or THF
3. Optimal reaction temperature: 60-80°C

Safety Measures:

• Wear PPE (nitrile gloves, safety goggles)
• Store separately from strong oxidizers

4. Case Studies

Case 1: Anticancer Drug Intermediate Synthesis

• Objective: Synthesize osimertinib intermediate
• Process: Buchwald-Hartwig amination using 2-Amino-5-bromopyrazine
• Yield: 82% (vs. 75% with 3-bromo isomer)

5. Client Success Stories

Client A: Top 10 Pharma Company (2023 Project)

• Challenge: Scale up BTK inhibitor production
• Solution: Optimized bromopyrazine coupling using our product
• Result: Reduced impurities from 5.2% to 1.8%, saving $2.1M annually

Client B: OLED Materials Manufacturer

• Application: Electron transport layer synthesis
• Outcome: Achieved 15% higher luminous efficiency vs. standard materials

6. Request Quotation or Sample

Contact our technical team for:

• Custom synthesis options
• Bulk pricing (10kg+ orders)
• COA and MSDS documentation

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