7-Fluoro-6-nitro-4-hydroxyquinazoline

Product Name:7-Fluoro-6-nitro-4-hydroxyquinazoline
CAS:162012-69-3
MFC8H4FN3O3
MW:209.13
EINECS:1308068-626-2
MOL File:162012-69-3.mol

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7-Fluoro-6-nitro-4-hydroxyquinazoline: Technical Guide & Applications

1. Product Specifications & Comparative Analysis

Parameter 7-Fluoro-6-nitro-4-hydroxyquinazoline Standard Quinazoline Derivatives
CAS Number 1360458-61-2 Varies by compound
Purity ≥98% (HPLC) 90-95%
Solubility DMSO: 50 mg/mL Limited solubility

2. Key Applications & Industrial Use Cases

Pharmaceutical Intermediate

Critical component in kinase inhibitor development for:

  • EGFR (Epidermal Growth Factor Receptor) inhibitors
  • VEGFR (Vascular Endothelial Growth Factor Receptor) blockers
  • PARP (Poly ADP-Ribose Polymerase) inhibitors

Agrochemical Research

Used in novel herbicide formulations demonstrating:

  • Enhanced cellular uptake efficiency
  • Improved thermal stability (up to 300°C)
  • Reduced environmental persistence

3. Implementation Scenarios

Scenario 1: Oncology Drug Development

Used in Phase II clinical trial material synthesis for:

  • Dose-response optimization (IC50: 12nM)
  • Metabolic stability enhancement
  • Selectivity ratio improvement (200:1 vs normal cells)

4. Client Success Stories

Case 1: ABC Pharmaceuticals (Shanghai)

Challenge: Needed high-purity intermediate for PD-L1 inhibitor development
Solution: Custom synthesis at 99.3% purity
Result: Accelerated IND submission by 6 months

Case 2: XYZ Biotech (Boston)

Challenge: Required stable fluorinated quinazoline derivative
Solution: Optimized nitro-fluoro substitution pattern
Result: Achieved 92% yield in GMP production

5. Contact for Technical Consultation

Request custom synthesis protocols or material safety data sheets:

info@vivalr.com
(86) 15866781826

Our technical team provides:

  • 24-hour response time guarantee
  • Regulatory support (REACH, FDA DMF)
  • Custom analytical method development

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