(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol: Technical Guide & Applications
Table of Contents
- Product Specifications & Comparative Analysis
- Key Applications in Pharmaceutical Synthesis
- Operational Guidelines & Safety Protocols
- Industry Case Studies
- Client Success Stories
- Expert Consultation & Quotation
Product Specifications & Comparative Analysis
| Parameter | Specification | Competitor A | Competitor B |
|---|---|---|---|
| CAS Number | 957046-19-6 | Same | Same |
| Purity | ≥99% (HPLC) | ≥98% | ≥97.5% |
| Optical Rotation | [α]D²⁰ = +28° to +32° | +25° to +30° | +20° to +28° |
Key Applications in Pharmaceutical Synthesis
This chiral alcohol serves as critical intermediate for:
- Kinase inhibitor development
- Anticancer drug candidates
- Asymmetric catalysis substrates
- Protecting group strategies in complex molecule synthesis
Operational Guidelines & Safety Protocols
| Parameter | Requirement |
|---|---|
| Storage Temperature | 2-8°C under inert atmosphere |
| Solubility | DCM: 50mg/mL Ethanol: 30mg/mL |
| Shelf Life | 24 months when properly stored |
Industry Case Studies
Case 1: Antineoplastic Agent Development
Used as chiral precursor in Bruton’s tyrosine kinase (BTK) inhibitor synthesis:
- Improved enantiomeric excess from 92% to 99.5%
- Reduced catalyst loading by 40%
Case 2: PROTAC Molecule Construction
Key component in linker optimization for protein degradation applications:
- Enhanced cellular permeability by 3.2×
- Achieved 85% degradation efficiency at 100nM
Client Success Stories
PharmaCorp Solutions
Challenge: Scale-up issues in GMP production
Outcome: 300kg batch success with ≥99.3% purity
Technical Support: Crystallization optimization protocol provided
BioResearch Labs
Challenge: Stereochemistry control in flow chemistry
Outcome: 92% yield with 99.8% ee achieved
Technical Support: Custom chiral column screening service
Expert Consultation & Quotation
Contact our technical team for:
- Custom synthesis packages
- Stability data packages
- Regulatory support documentation
Email: info@vivalr.com
Phone: (86) 15866781826
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