Table of Contents
(3,5-Diphenylphenyl)boronic Acid: Product Overview
Basic Parameters
| Parameter | Value |
|---|---|
| Chemical Formula | C18H15BO2 |
| CAS Number | 874299-54-6 |
| Molecular Weight | 274.12 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity | ≥97% (HPLC) |
| Melting Point | 250-255°C |
| Storage Conditions | 2-8°C, dry, protected from light |
Comparative Analysis with Related Boronic Acids
| Property | (3,5-Diphenylphenyl)boronic Acid | Phenylboronic Acid | 4-Carboxyphenylboronic Acid |
|---|---|---|---|
| Solubility in THF | High | Moderate | Low |
| Thermal Stability | Excellent (>300°C) | Good (200°C) | Moderate (150°C) |
| Catalytic Efficiency | Superior in cross-couplings | Standard | Limited |
| Pharma Applications | Kinase inhibitor synthesis | Generic API intermediates | Bioconjugation |
Key Industrial Applications
Suzuki-Miyaura Cross-Coupling Reactions
Widely used as a catalyst in C-C bond formation for synthesizing biaryl compounds, critical in pharmaceutical APIs and advanced materials.
OLED Material Development
Serves as electron-transport layer precursor in organic light-emitting diodes (OLEDs), enhancing device efficiency by 15-20% compared to traditional materials.
Biomedical Research
Essential intermediate for kinase inhibitors (e.g., EGFR inhibitors) and PROTAC degraders targeting cancer-related proteins.
Operational Best Practices
Handling Procedures
- Use nitrogen atmosphere for moisture-sensitive reactions
- Optimize molar ratio between 1:1.2 and 1:1.5 in coupling reactions
- Pre-dry solvent to ≤50 ppm H2O content
Storage Recommendations
- Maintain argon blanket in storage containers
- Monitor humidity levels (<30% RH)
- Use amber glass containers for light sensitivity
Client Success Stories
Case 1: Oncology Drug Development
Client: Top 10 Global Pharma Company
Challenge: Low yield (38%) in Bruton’s tyrosine kinase inhibitor synthesis
Solution: Implemented (3,5-Diphenylphenyl)boronic Acid in optimized Pd/XPhos catalyst system
Outcome: Achieved 82% yield with >99% purity, reducing production costs by $2.8M annually
Case 2: Flexible OLED Manufacturing
Client: Leading Display Manufacturer
Challenge: Device lifetime <10,000 hours under high brightness
Solution: Incorporated boronic acid derivative in electron injection layer
Outcome: Extended operational lifespan to 25,000+ hours, enabling premium product tier
Request Customized Solutions
Optimize your synthesis protocols with our technical expertise:
Email: info@vivalr.com
Phone: (86) 15866781826
Why Choose Us?
- Batch-to-batch consistency: ±1% purity variance
- Custom functionalization services available
- Regulatory support for FDA/EMA filings


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